Fusobacterium necrophorum leukotoxoid vaccine for prevention of liver abscesses

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dc.contributor.author Saginala, S.
dc.contributor.author Lechtenberg, K.F.
dc.contributor.author Kemp, Kenneth E.
dc.contributor.author Hine, P.M.
dc.contributor.author Nagaraja, Tiruvoor G.
dc.contributor.author Chengappa, M. M.
dc.date.accessioned 2010-09-02T17:02:34Z
dc.date.available 2010-09-02T17:02:34Z
dc.date.issued 2010-09-02T17:02:34Z
dc.identifier.uri http://hdl.handle.net/2097/4766
dc.description.abstract The efficacy of Fusobacterium necrophorum crude leukotoxoid vaccine to immunize and protect steers against experimentally induced liver abscesses was evaluated. The vaccine consisted of cell-free culture supernatant of a high leukotoxin-producing strain of F. necrophorum, inactivated with formalin and homogenized with an oil emulsion adjuvant. Vaccine was injected subcutaneously on days 0 and 21. Blood samples were collected weekly to monitor immune response. Three weeks after the second vaccination, steers were injected intraportally with F. necrophorum culture to induce liver abscesses. Three weeks later (day 63), steers were euthanatized and necropsied; livers were examined, and protection was assessed. Anti-leukotoxin antibody titers in the control steers generally did not differ from the baseline (week 0) titers. The titers in the vaccinated groups increased, more so after the second injection, and the increase was generally dose dependent. At necropsy, all steers in the control group had liver abscesses. In the vaccinated groups, two out of five steers in the 1.0 ml group and one each in the 2.0, 5.0, and 2.25 ml (concentrated) groups had liver abscesses. The difference suggests a protective effect of antileukotoxin antibodies against experimentally induced liver abscesses. en_US
dc.publisher Kansas State University. Agricultural Experiment Station and Cooperative Extension Service en_US
dc.relation.isPartOf Kansas Agricultural Experiment Station contribution; no. 97-309-S en_US
dc.relation.isPartOf Report of progress (Kansas State University. Agricultural Experiment Station and Cooperative Extension Service); 804 en_US
dc.relation.isPartOf Cattlemen's Day, 1998 en_US
dc.subject Beef en_US
dc.subject Liver abscesses en_US
dc.subject Fusobacterium necrophorum en_US
dc.subject Leukotoxoid vaccine en_US
dc.title Fusobacterium necrophorum leukotoxoid vaccine for prevention of liver abscesses en_US
dc.type Conference paper en_US
dc.date.published 1998 en_US
dc.citation.epage 43 en_US
dc.citation.spage 40 en_US
dc.description.conference Cattlemen's Day, 1998, Kansas State University, Manhattan, KS, March 6, 1998 en_US
dc.contributor.authoreid tnagaraj en_US
dc.contributor.authoreid chengapa en_US
dc.contributor.authoreid kekemp en_US

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