dc.contributor.author |
Saginala, S. |
|
dc.contributor.author |
Lechtenberg, K.F. |
|
dc.contributor.author |
Kemp, Kenneth E. |
|
dc.contributor.author |
Hine, P.M. |
|
dc.contributor.author |
Nagaraja, Tiruvoor G. |
|
dc.contributor.author |
Chengappa, M. M. |
|
dc.date.accessioned |
2010-09-02T17:02:34Z |
|
dc.date.available |
2010-09-02T17:02:34Z |
|
dc.date.issued |
2010-09-02T17:02:34Z |
|
dc.identifier.uri |
http://hdl.handle.net/2097/4766 |
|
dc.description.abstract |
The efficacy of Fusobacterium
necrophorum crude leukotoxoid vaccine to
immunize and protect steers against experimentally
induced liver abscesses was evaluated.
The vaccine consisted of cell-free
culture supernatant of a high leukotoxin-producing
strain of F. necrophorum, inactivated
with formalin and homogenized with an
oil emulsion adjuvant. Vaccine was injected
subcutaneously on days 0 and 21. Blood
samples were collected weekly to monitor
immune response. Three weeks after the
second vaccination, steers were injected
intraportally with F. necrophorum culture to
induce liver abscesses. Three weeks later (day
63), steers were euthanatized and necropsied;
livers were examined, and protection was
assessed. Anti-leukotoxin antibody titers in
the control steers generally did not differ
from the baseline (week 0) titers. The titers
in the vaccinated groups increased, more so
after the second injection, and the increase
was generally dose dependent. At necropsy,
all steers in the control group had liver
abscesses. In the vaccinated groups, two out
of five steers in the 1.0 ml group and one
each in the 2.0, 5.0, and 2.25 ml (concentrated)
groups had liver abscesses. The difference
suggests a protective effect of antileukotoxin antibodies against experimentally
induced liver abscesses. |
en_US |
dc.publisher |
Kansas State University. Agricultural Experiment Station and Cooperative Extension Service |
en_US |
dc.relation.isPartOf |
Kansas Agricultural Experiment Station contribution; no. 97-309-S |
en_US |
dc.relation.isPartOf |
Report of progress (Kansas State University. Agricultural Experiment Station and Cooperative Extension Service); 804 |
en_US |
dc.relation.isPartOf |
Cattlemen's Day, 1998 |
en_US |
dc.subject |
Beef |
en_US |
dc.subject |
Liver abscesses |
en_US |
dc.subject |
Fusobacterium necrophorum |
en_US |
dc.subject |
Leukotoxoid vaccine |
en_US |
dc.title |
Fusobacterium necrophorum leukotoxoid vaccine for prevention of liver abscesses |
en_US |
dc.type |
Conference paper |
en_US |
dc.date.published |
1998 |
en_US |
dc.citation.epage |
43 |
en_US |
dc.citation.spage |
40 |
en_US |
dc.description.conference |
Cattlemen's Day, 1998, Kansas State University, Manhattan, KS, March 6, 1998 |
en_US |
dc.contributor.authoreid |
tnagaraj |
en_US |
dc.contributor.authoreid |
chengapa |
en_US |
dc.contributor.authoreid |
kekemp |
en_US |