Potential mechanisms of cancer prevention by weight control

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dc.contributor.author Jiang, Yu
dc.contributor.author Wang, Weiqun
dc.date.accessioned 2009-03-03T23:00:28Z
dc.date.available 2009-03-03T23:00:28Z
dc.date.issued 2009-03-03T23:00:28Z
dc.identifier.uri http://hdl.handle.net/2097/1281
dc.description.abstract Weight control via dietary caloric restriction and/or physical activity has been demonstrated in animal models for cancer prevention. However, the underlying mechanisms are not fully understood. Body weight loss due to negative energy balance significantly reduces some metabolic growth factors and endocrinal hormones such as IGF-1, leptin, adiponectin, and glucocorticoids, etc., that may be associated with anti-cancer mechanisms. In this review, we summarized the recent studies related to weight control and growth factors. The potential molecular targets focused on those growth factors- and hormones-dependent cellular signaling pathways are further discussed. It appears that multiple factors and multiple signaling cascades, especially for Ras-MAPK-proliferation and PI3K-Akt-anti-apoptosis, could be involved in response to weight change by dietary calorie restriction and/or exercise training. Considering prevalence of obesity or overweight that becomes apparent over the world, understanding the underlying mechanisms among weight control, endocrine change and cancer risk is critically important. Future studies using "-omics" technologies will be warrant for a broader and deeper mechanistic information regarding cancer prevention by weight control. en
dc.rights Electronic version of an article published as Yu Jiang and Weiqun Wang, Potential Mechanisms of Cancer Prevention by Weight Control, Biophysical Reviews and Letters (2008): 3(3):421-437. © Copyright World Scientific Publishing Company. http://www.worldscinet.com/brl/brl.shtml en
dc.subject Weight control en
dc.subject Dietary calorie restriction en
dc.subject Physical activity en
dc.subject IGF-1 en
dc.subject Leptin en
dc.subject Cancer prevention en
dc.subject Glucocorticoids
dc.title Potential mechanisms of cancer prevention by weight control en
dc.type Article (author version) en
dc.date.published 2008 en
dc.citation.epage 437 en
dc.citation.issue 3 en
dc.citation.jtitle Biophysical reviews and letters en
dc.citation.spage 421 en
dc.citation.volume 3 en
dc.contributor.authoreid yjiang en
dc.contributor.authoreid wwang en

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