Weight Loss via Exercise with Controlled Dietary Intake May Affect Phospholipid Profile for Cancer Prevention in Murine Skin Tissues

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dc.contributor.author Ouyang, Ping
dc.contributor.author Jiang, Yu
dc.contributor.author Doan, Hieu M.
dc.contributor.author Xie, Linglin
dc.contributor.author Vasquez, David
dc.contributor.author Welti, Ruth
dc.contributor.author Su, Xiaoyu
dc.contributor.author Lu, Nanyan
dc.contributor.author Herndon, Betty
dc.contributor.author Yang, Shie-Shien
dc.contributor.author Jeannotte, Richard
dc.contributor.author Wang, Weiqun
dc.date.accessioned 2010-04-26T19:55:34Z
dc.date.available 2010-04-26T19:55:34Z
dc.date.issued 2010-04-26T19:55:34Z
dc.identifier.uri http://hdl.handle.net/2097/3745
dc.description.abstract Exercise has been linked to a reduced cancer risk in animal models. However, the underlying mechanisms are unclear. This study assessed the impact of exercise with dietary consideration on the phospholipid profile in TPA-induced mouse skin tissues. CD-1 mice were randomly assigned to one of the three groups: ad libitum-fed sedentary control, ad libitum-fed treadmill exercise at 13.4 m/min for 60 min/d, 5 d/wk (Ex+AL), and treadmill exercised but pair-fed with the same amount as the control (Ex+PF). After 14 wks, Ex+PF but not Ex+AL mice demonstrated ~25% decrease in both body weight and body fat when compared to the controls. Of the total 338 phospholipids determined by electrospray ionization tandem mass spectrometry, 57 were significantly changed, and 25 species could distinguish effects of exercise and diet treatments in a stepwise discriminant analysis. A 36-75% decrease of phosphatidylinositol (PI) levels in Ex+PF mice occurred along with a significant reduction of PI3K in TPA-induced skin epidermis, as measured by both western blotting and immunohistochemistry. In addition, near 2-fold increase of the long chain polyunsaturated fatty acids, docosahexaenoic and docosapentaenoic acids, in phosphatidylcholines, phosphatidylethanolamines, and lysophosphatidylethanolamines wasobserved in the Ex+PF group. Microarray analysis indicated that the expression of fatty acid elongase-1 increased. Taken together, these data indicate that exercise with controlled dietary intake but not exercise alone significantly reduced body weight and body fat as well as modified the phospholipid profile, which may contribute to cancer prevention by reducing TPA-induced PI3K and by enhancing -3 fatty acid elongation. en_US
dc.relation.uri http://cancerpreventionresearch.aacrjournals.org/content/3/4/466.abstract en_US
dc.subject Weight control en_US
dc.subject Excercise en_US
dc.subject Phospholipids en_US
dc.subject Skin tissues en_US
dc.subject Mice en_US
dc.title Weight Loss via Exercise with Controlled Dietary Intake May Affect Phospholipid Profile for Cancer Prevention in Murine Skin Tissues en_US
dc.type Article (author version) en_US
dc.date.published 2010 en_US
dc.citation.doi doi: 10.1158/1940-6207.CAPR-09-0021 en_US
dc.citation.epage 477 en_US
dc.citation.issue 4 en_US
dc.citation.jtitle Cancer Prevention Research en_US
dc.citation.spage 466 en_US
dc.citation.volume 3 en_US
dc.contributor.authoreid welti en_US
dc.contributor.authoreid ssyang en_US
dc.contributor.authoreid wwang en_US


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