Brain activation during dual-task processing is associated with cardiorespiratory fitness and performance in older adults

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dc.contributor.author Wong, C. N.
dc.contributor.author Chaddock-Heyman, L.
dc.contributor.author Voss, M. W.
dc.contributor.author Burzynska, A. Z.
dc.contributor.author Basak, C.
dc.contributor.author Erickson, K. I.
dc.contributor.author Prakash, R. S.
dc.contributor.author Szabo-Reed, A. N.
dc.contributor.author Phillips, S. M.
dc.contributor.author Wojcicki, T.
dc.contributor.author Mailey, Emily L.
dc.contributor.author McAuley, E.
dc.contributor.author Kramer, A. F.
dc.date.accessioned 2016-04-06T15:00:36Z
dc.date.available 2016-04-06T15:00:36Z
dc.identifier.uri http://hdl.handle.net/2097/32338
dc.description Citation: Wong, C. N., Chaddock-Heyman, L., Voss, M. W., Burzynska, A. Z., Basak, C., Erickson, K. I., . . . Kramer, A. F. (2015). Brain activation during dual-task processing is associated with cardiorespiratory fitness and performance in older adults. Frontiers in Aging Neuroscience, 7, 10. doi:10.3389/fnagi.2015.00154
dc.description Higher cardiorespiratory fitness is associated with better cognitive performance and enhanced brain activation. Yet, the extent to which cardiorespiratory fitness-related brain activation is associated with better cognitive performance is not well understood. In this cross-sectional study, we examined whether the association between cardiorespiratory fitness and executive function was mediated by greater prefrontal cortex activation in healthy older adults. Brain activation was measured during dual-task performance with functional magnetic resonance imaging in a sample of 128 healthy older adults (59-80 years). Higher cardiorespiratory fitness was associated with greater activation during dual-task processing in several brain areas including the anterior cingulate and supplementary motor cortex (ACC/SMA), thalamus and basal ganglia, right motor/somatosensory cortex and middle frontal gyrus, and left somatosensory cortex, controlling for age, sex, education, and gray matter volume. Of these regions, greater ACC/SMA activation mediated the association between cardiorespiratory fitness and dual-task performance. We provide novel evidence that cardiorespiratory fitness may support cognitive performance by facilitating brain activation in a core region critical for executive function.
dc.relation.uri https://doi.org/10.3389/fnagi.2015.00154
dc.rights Attribution 4.0 International (CC BY 4.0)
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject Exercise
dc.subject Aging
dc.subject Fmri
dc.subject Dual-Task
dc.subject Cardiorespiratory Fitness
dc.subject Executive
dc.title Brain activation during dual-task processing is associated with cardiorespiratory fitness and performance in older adults
dc.type Article
dc.date.published 2015
dc.citation.doi 10.3389/fnagi.2015.00154
dc.citation.issn 1663-4365
dc.citation.issue JUL
dc.citation.jtitle Frontiers in Aging Neuroscience
dc.citation.spage 10
dc.citation.volume 7
dc.contributor.authoreid emailey


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