Brain activation during dual-task processing is associated with cardiorespiratory fitness and performance in older adults
| dc.citation.doi | 10.3389/fnagi.2015.00154 | |
| dc.citation.issn | 1663-4365 | |
| dc.citation.issue | JUL | |
| dc.citation.jtitle | Frontiers in Aging Neuroscience | |
| dc.citation.spage | 10 | |
| dc.citation.volume | 7 | |
| dc.contributor.author | Wong, C. N. | |
| dc.contributor.author | Chaddock-Heyman, L. | |
| dc.contributor.author | Voss, M. W. | |
| dc.contributor.author | Burzynska, A. Z. | |
| dc.contributor.author | Basak, C. | |
| dc.contributor.author | Erickson, K. I. | |
| dc.contributor.author | Prakash, R. S. | |
| dc.contributor.author | Szabo-Reed, A. N. | |
| dc.contributor.author | Phillips, S. M. | |
| dc.contributor.author | Wojcicki, T. | |
| dc.contributor.author | Mailey, Emily L. | |
| dc.contributor.author | McAuley, E. | |
| dc.contributor.author | Kramer, A. F. | |
| dc.contributor.authoreid | emailey | |
| dc.date.accessioned | 2016-04-06T15:00:36Z | |
| dc.date.available | 2016-04-06T15:00:36Z | |
| dc.date.published | 2015 | |
| dc.description | Citation: Wong, C. N., Chaddock-Heyman, L., Voss, M. W., Burzynska, A. Z., Basak, C., Erickson, K. I., . . . Kramer, A. F. (2015). Brain activation during dual-task processing is associated with cardiorespiratory fitness and performance in older adults. Frontiers in Aging Neuroscience, 7, 10. doi:10.3389/fnagi.2015.00154 | |
| dc.description | Higher cardiorespiratory fitness is associated with better cognitive performance and enhanced brain activation. Yet, the extent to which cardiorespiratory fitness-related brain activation is associated with better cognitive performance is not well understood. In this cross-sectional study, we examined whether the association between cardiorespiratory fitness and executive function was mediated by greater prefrontal cortex activation in healthy older adults. Brain activation was measured during dual-task performance with functional magnetic resonance imaging in a sample of 128 healthy older adults (59-80 years). Higher cardiorespiratory fitness was associated with greater activation during dual-task processing in several brain areas including the anterior cingulate and supplementary motor cortex (ACC/SMA), thalamus and basal ganglia, right motor/somatosensory cortex and middle frontal gyrus, and left somatosensory cortex, controlling for age, sex, education, and gray matter volume. Of these regions, greater ACC/SMA activation mediated the association between cardiorespiratory fitness and dual-task performance. We provide novel evidence that cardiorespiratory fitness may support cognitive performance by facilitating brain activation in a core region critical for executive function. | |
| dc.identifier.uri | http://hdl.handle.net/2097/32338 | |
| dc.relation.uri | https://doi.org/10.3389/fnagi.2015.00154 | |
| dc.rights | Attribution 4.0 International (CC BY 4.0) | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Exercise | |
| dc.subject | Aging | |
| dc.subject | Fmri | |
| dc.subject | Dual-Task | |
| dc.subject | Cardiorespiratory Fitness | |
| dc.subject | Executive | |
| dc.title | Brain activation during dual-task processing is associated with cardiorespiratory fitness and performance in older adults | |
| dc.type | Article |
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