Effects of an acute enteric disease challenge on IGF-1 and IGFBP-3 gene expression in porcine skeletal muscle
dc.citation.epage | 52 | en_US |
dc.citation.spage | 48 | en_US |
dc.contributor.ORCID | orcid.org/0000-0002-9150-169X | |
dc.contributor.author | Johnson, B.J. | |
dc.contributor.author | Kayser, J.P. | |
dc.contributor.author | Dunn, J.D. | |
dc.contributor.author | Waylan, A.T. | |
dc.contributor.author | Drtiz, S.S. | |
dc.contributor.author | Nietfeld, Jerome C. | |
dc.contributor.author | Minton, J. Ernest | |
dc.contributor.authoreid | dritz | en_US |
dc.contributor.authoreid | jcnietfe | en_US |
dc.contributor.authoreid | eminton | en_US |
dc.date.accessioned | 2010-02-08T18:12:04Z | |
dc.date.available | 2010-02-08T18:12:04Z | |
dc.date.issued | 2010-02-08T18:12:04Z | |
dc.date.published | 2002 | en_US |
dc.description.abstract | Eighteen pigs (initial weight 25 lb and approximately 5 wk of age) were used in a 14-d trial to determine the effects of an acute Salmonella enterica serotype typhimurium (ST) disease challenge on both circulating insulinlike growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) and steady-state IGF-1 and IGFBP-3 mRNA levels in skeletal muscle. Muscle biopsies and blood samples were obtained from all pigs on d 0, 3, 7, and 14 relative to ST-challenge. Results suggest that an acute ST-challenge decreased circulating IGF-1 levels on d 3 and 7 but did not affect circulating IGFBP-3 concentrations. Additionally, ST-challenge had no effect on steady-state IGF-1 and IGFBP-3 mRNA levels in skeletal muscle following the onset of disease. These data suggest that an acute enteric disease insult can lower circulating IGF-1 but more chronic conditions may be necessary to affect local IGF-1 levels in skeletal muscle. Additionally, the increased muscle IGF-1 mRNA without increased IGFBP-3 levels on d 14 most likely results in increased IGF-1 synthesis that contributes to circulating IGF-1 concentrations. | en_US |
dc.description.conference | Swine Day, Manhattan, KS, November 14, 2002 | en_US |
dc.identifier.uri | http://hdl.handle.net/2097/2479 | |
dc.publisher | Kansas State University. Agricultural Experiment Station and Cooperative Extension Service | en_US |
dc.relation.isPartOf | Swine day, 2002 | en_US |
dc.relation.isPartOf | Kansas Agricultural Experiment Station contribution; no. 03-120-S | en_US |
dc.relation.isPartOf | Report of progress (Kansas State University. Agricultural Experiment Station and Cooperative Extension Service); 897 | en_US |
dc.subject | Pigs | en_US |
dc.subject | Salmonella | en_US |
dc.subject | Muscle | en_US |
dc.subject | IGF-1, IGFBP-3 | en_US |
dc.subject | Swine | en_US |
dc.title | Effects of an acute enteric disease challenge on IGF-1 and IGFBP-3 gene expression in porcine skeletal muscle | en_US |
dc.type | Conference paper | en_US |