The effects of short-term fish oil supplementation on pulmonary function and airway inflammation following a high-fat meal.

dc.citation.doi10.1007/s00421-013-2792-7en_US
dc.citation.epage682en_US
dc.citation.issue4en_US
dc.citation.jtitleEuropean journal of applied physiologyen_US
dc.citation.spage675en_US
dc.citation.volume114en_US
dc.contributor.authorHarms, Craig A.
dc.contributor.authorRosenkranz, Sara K.
dc.contributor.authorAde, C. J.
dc.contributor.authoreidsararose
dc.date.accessioned2014-05-08T20:49:07Z
dc.date.available2014-05-08T20:49:07Z
dc.date.issued2014-05-08
dc.date.published2014en_US
dc.description.abstractIntroduction Many environmental and dietary influences can cause immune cells to produce biological mediators that increase airway inflammation. A high-fat meal (HFM) is one stimulus that increases airway inflammation in healthy individuals. Supplementation with omega-3 fatty acids can reduce inflammation systemically and may be beneficial to the airways. Purpose To determine if omega-3 fatty acid supplementation via fish oil would mitigate the airway inflammatory response induced by a single HFM. Methods Seventeen non-asthmatic men (22 ± 2 years.) were supplemented with 3,000 mg × day⁻¹ fish oil or a placebo for 3 weeks. Fractional exhaled nitric oxide (FENO; a marker of airway inflammation), impulse oscillometry (a measure of respiratory impedance), pulmonary function, and triglycerides were measured prior to and 2 h following a HFM. Results Following a HFM, triglycerides increased in both fish oil and placebo groups compared to pre-HFM (~59 and ~49 %, respectively, p < 0.05). The percent increase in FENO was greater in the placebo group compared to the fish oil group (25.7 ± 16.7 vs. −1.99 ± 10.5 %, respectively, p < 0.05). A significant correlation was observed between blood triglycerides and FENO in the placebo group (r = 0.61; p < 0.05), but not the fish oil group (p = 0.21). Conclusion A single HFM increases airway inflammation and omega-3 fatty acid supplementation via fish oil protects against HFM associated changes in airway health.en_US
dc.identifier.urihttp://hdl.handle.net/2097/17713
dc.language.isoen_USen_US
dc.relation.urihttp://link.springer.com/article/10.1007/s00421-013-2792-7en_US
dc.subjectAirway inflammationen_US
dc.subjectHigh-faten_US
dc.subjectFish oilen_US
dc.subjectPulmonary functionen_US
dc.titleThe effects of short-term fish oil supplementation on pulmonary function and airway inflammation following a high-fat meal.en_US
dc.typeArticle (author version)en_US

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