Blinded, randomized, placebo-controlled study of the efficacy of bupivacaine liposomal suspension using static body weight distribution and subjective pain scoring in dogs after tibial plateau leveling osteotomy (TPLO) surgery
dc.contributor.author | Aldrich, Lauren A. | |
dc.date.accessioned | 2021-08-30T14:55:55Z | |
dc.date.available | 2021-08-30T14:55:55Z | |
dc.date.graduationmonth | August | en_US |
dc.date.modified | 2021-09-02 | |
dc.date.published | 2021 | en_US |
dc.description.abstract | Objective: To compare the analgesic effect of surgical wound infiltration with liposomal bupivacaine (LB) to saline placebo in dogs after tibial plateau leveling osteotomy (TPLO). Study Design: Blinded, randomized, placebo-controlled clinical prospective study Animals: 15 client-owned dogs receiving liposomal bupivacaine and 17 dogs receiving an equivalent volume of saline placebo, all with confirmed unilateral cranial cruciate ligament insufficiency. Methods: Preoperatively and up to 48 hours after surgery, Glasgow Composite Measure Short Form (CMPS-SF) pain scores were assigned and using a weight distribution platform, static body weight distribution (%BW[subsctipt dist]) to the operated limb was measured. Postoperatively, dogs also received carprofen 2.2 mg/kg subcutaneously every 12 hours. Rescue analgesia was provided. Treatment success was defined as not requiring rescue analgesia over the 48 hour postoperative period. Results: There was no difference between treatment success, postoperative opioid consumption, CMPS-SF pain scores, or %BW[subscript dist] in dogs that received surgical wound infiltration with LB compared with those receiving saline placebo, following TPLO. There was no linear correlation between CMPS-SF pain scores and %BW[subscript dist]. Conclusion: For the population of dogs that underwent TPLO and received postoperative carprofen at our institution, LB did not provide an analgesic effect discernable by success/failure analysis, CMPS-SF pain scores, or %BW[subscript dist] measurement using a weight distribution platform, compared with saline placebo. Clinical Significance (or Impact): LB may not provide detectable analgesia for dogs recovering from TPLO and receiving postoperative carprofen. | en_US |
dc.description.advisor | David Upchurch | en_US |
dc.description.degree | Master of Science in Biomedical Sciences | en_US |
dc.description.department | Department of Clinical Sciences | en_US |
dc.description.level | Masters | en_US |
dc.description.sponsorship | Department of Clinical Sciences of the College of Veterinary Medicine, Kansas State University | en_US |
dc.identifier.uri | https://hdl.handle.net/2097/41687 | |
dc.language.iso | en_US | en_US |
dc.subject | Liposomal bupivacaine | en_US |
dc.subject | Canine | en_US |
dc.title | Blinded, randomized, placebo-controlled study of the efficacy of bupivacaine liposomal suspension using static body weight distribution and subjective pain scoring in dogs after tibial plateau leveling osteotomy (TPLO) surgery | en_US |
dc.type | Thesis | en_US |