Blinded, randomized, placebo-controlled study of the efficacy of bupivacaine liposomal suspension using static body weight distribution and subjective pain scoring in dogs after tibial plateau leveling osteotomy (TPLO) surgery

Date

2021

Journal Title

Journal ISSN

Volume Title

Publisher

Kansas State University

Abstract

Objective: To compare the analgesic effect of surgical wound infiltration with liposomal bupivacaine (LB) to saline placebo in dogs after tibial plateau leveling osteotomy (TPLO).

Study Design: Blinded, randomized, placebo-controlled clinical prospective study

Animals: 15 client-owned dogs receiving liposomal bupivacaine and 17 dogs receiving an equivalent volume of saline placebo, all with confirmed unilateral cranial cruciate ligament insufficiency.

Methods: Preoperatively and up to 48 hours after surgery, Glasgow Composite Measure Short Form (CMPS-SF) pain scores were assigned and using a weight distribution platform, static body weight distribution (%BW[subsctipt dist]) to the operated limb was measured. Postoperatively, dogs also received carprofen 2.2 mg/kg subcutaneously every 12 hours. Rescue analgesia was provided. Treatment success was defined as not requiring rescue analgesia over the 48 hour postoperative period.

Results: There was no difference between treatment success, postoperative opioid consumption, CMPS-SF pain scores, or %BW[subscript dist] in dogs that received surgical wound infiltration with LB compared with those receiving saline placebo, following TPLO. There was no linear correlation between CMPS-SF pain scores and %BW[subscript dist].

Conclusion: For the population of dogs that underwent TPLO and received postoperative carprofen at our institution, LB did not provide an analgesic effect discernable by success/failure analysis, CMPS-SF pain scores, or %BW[subscript dist] measurement using a weight distribution platform, compared with saline placebo.

Clinical Significance (or Impact): LB may not provide detectable analgesia for dogs recovering from TPLO and receiving postoperative carprofen.

Description

Keywords

Liposomal bupivacaine, Canine

Graduation Month

August

Degree

Master of Science in Biomedical Sciences

Department

Department of Clinical Sciences

Major Professor

David Upchurch

Date

Type

Thesis

Citation