Selenium, but Not Lycopene or Vitamin E, Decreases Growth of Transplantable Dunning R3327-H Rat Prostate Tumors

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dc.contributor.author Lindshield, Brian L.
dc.contributor.author Ford, Nikki A.
dc.contributor.author Canene-Adams, Kirstie
dc.contributor.author Diamond, Alan M.
dc.contributor.author Wallig, Matthew A.
dc.contributor.author Erdman, John W. Jr.
dc.date.accessioned 2010-08-31T15:03:58Z
dc.date.available 2010-08-31T15:03:58Z
dc.date.issued 2010-08-31T15:03:58Z
dc.identifier.uri http://hdl.handle.net/2097/4758
dc.description.abstract Background: Lycopene, selenium, and vitamin E are three micronutrients commonly consumed and supplemented by men diagnosed with prostate cancer. However, it is not clear whether consumption of these compounds, alone or in combination, results in improved outcomes. Methodology/Principal Findings: We evaluated the effects of dietary lycopene (250 mg/kg diet), selenium (methylselenocysteine, 1 mg/kg diet), and vitamin E (γ-tocopherol, 200 mg/kg diet) alone and in combination on the growth of androgen-dependent Dunning R3327-H rat prostate adenocarcinomas in male, Copenhagen rats. AIN-93G diets containing these micronutrients were prefed for 4 to 6 weeks prior to tumor implantation by subcutaneous injection. Tumors were allowed to grow for ~18 weeks. Across diet groups, methylselenocysteine consumption decreased final tumor area (P = 0.003), tumor weight (P = 0.003), and the tumor weight/body weight ratio (P = 0.003), but lycopene and γ-tocopherol consumption intake did not alter any of these measures. There were no significant interactions among nutrient combinations on tumor growth. Methylselenocysteine consumption also led to small, but significant decreases in body weight (P = 0.007), food intake (P = 0.012), and body weight gain/food intake ratio (P = 0.022). However, neither body weight nor gain/food intake ratio was correlated with tumor weight. Methylselenocysteine, lycopene, and γ-tocopherol consumed alone and in combination did not alter serum testosterone or dihydrotestosterone concentrations; tumor proliferation or apoptosis rates. In addition, the diets also did not alter tumor or prostate androgen receptor, probasin, selenoprotein 15, selenoprotein P, or selenium binding protein 2 mRNA expression. However, using castration and finasteride-treated tissues from a previous study, we found that androgen ablation altered expression of these selenium-associated proteins. Conclusions: Of the three micronutrients tested, only methylselenocysteine consumption reduced growth of transplantable Dunning R3327-H prostate tumors, albeit through an unresolved mechanism. en_US
dc.relation.uri http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0010423 en_US
dc.subject Selenium en_US
dc.subject Lycopene en_US
dc.subject Vitamin E en_US
dc.subject Prostate cancer en_US
dc.subject Diet en_US
dc.title Selenium, but Not Lycopene or Vitamin E, Decreases Growth of Transplantable Dunning R3327-H Rat Prostate Tumors en_US
dc.type Article (publisher version) en_US
dc.date.published 2010 en_US
dc.citation.doi doi:10.1371/journal.pone.0010423 en_US
dc.citation.issue 4 en_US
dc.citation.jtitle PLos One en_US
dc.citation.spage e10423 en_US
dc.citation.volume 5 en_US
dc.contributor.authoreid blindsh en_US


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