Ultrafast Dynamics of a Nucleobase Analogue Illuminated by a Short Intense X-ray Free Electron Laser Pulse

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dc.contributor.author Nagaya, K.
dc.contributor.author Motomura, K.
dc.contributor.author Kukk, E.
dc.contributor.author Fukuzawa, H.
dc.contributor.author Wada, S.
dc.contributor.author Tachibana, T.
dc.contributor.author Ito, Y.
dc.contributor.author Mondal, S.
dc.contributor.author Sakai, T.
dc.contributor.author Matsunami, K.
dc.contributor.author Koga, R.
dc.contributor.author Ohmura, S.
dc.contributor.author Takahashi, Y.
dc.contributor.author Kanno, M.
dc.contributor.author Rudenko, Artem
dc.contributor.author Nicolas, C.
dc.contributor.author Liu, X. J.
dc.contributor.author Zhang, Y.
dc.contributor.author Chen, J.
dc.contributor.author Anand, M.
dc.contributor.author Jiang, Y. H.
dc.contributor.author Kim, D. E.
dc.contributor.author Tono, K.
dc.contributor.author Yabashi, M.
dc.contributor.author Kono, H.
dc.contributor.author Miron, C.
dc.contributor.author Yao, M.
dc.contributor.author Ueda, K.
dc.date.accessioned 2017-04-10T20:00:09Z
dc.date.available 2017-04-10T20:00:09Z
dc.identifier.uri http://hdl.handle.net/2097/35354
dc.description Citation: Nagaya, K., Motomura, K., Kukk, E., Fukuzawa, H., Wada, S., Tachibana, T., . . . Ueda, K. (2016). Ultrafast Dynamics of a Nucleobase Analogue Illuminated by a Short Intense X-ray Free Electron Laser Pulse. Physical Review X, 6(2), 9. doi:10.1103/PhysRevX.6.021035
dc.description.abstract Understanding x-ray radiation damage is a crucial issue for both medical applications of x rays and x-ray free-electron-laser (XFEL) science aimed at molecular imaging. Decrypting the charge and fragmentation dynamics of nucleobases, the smallest units of a macro-biomolecule, contributes to a bottom-up understanding of the damage via cascades of phenomena following x-ray exposure. We investigate experimentally and by numerical simulations the ultrafast radiation damage induced on a nucleobase analogue (5-iodouracil) by an ultrashort (10 fs) high-intensity radiation pulse generated by XFEL at SPring-8 Angstrom Compact free electron Laser (SACLA). The present study elucidates a plausible underlying radiosensitizing mechanism of 5-iodouracil. This mechanism is independent of the exact composition of 5-iodouracil and thus relevant to other such radiosensitizers. Furthermore, we found that despite a rapid increase of the net molecular charge in the presence of iodine, and of the ultrafast release of hydrogen, the other atoms are almost frozen within the 10-fs duration of the exposure. This validates single-shot molecular imaging as a consistent approach, provided the radiation pulse used is brief enough.
dc.relation.uri https://doi.org/10.1103/PhysRevX.6.021035
dc.rights Attribution 3.0 Unported (CC BY 3.0)
dc.rights.uri https://creativecommons.org/licenses/by/3.0/
dc.subject Ionization
dc.subject Charge
dc.subject Molecules
dc.subject Operation
dc.subject Region
dc.subject Atoms
dc.title Ultrafast Dynamics of a Nucleobase Analogue Illuminated by a Short Intense X-ray Free Electron Laser Pulse
dc.type Article
dc.date.published 2016
dc.citation.doi 10.1103/PhysRevX.6.021035
dc.citation.issn 2160-3308
dc.citation.issue 2
dc.citation.jtitle Physical Review X
dc.citation.spage 9
dc.citation.volume 6
dc.contributor.authoreid rudenko
dc.contributor.kstate Rudenko, Artem

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