Ultrafast Dynamics of a Nucleobase Analogue Illuminated by a Short Intense X-ray Free Electron Laser Pulse
dc.citation.doi | 10.1103/PhysRevX.6.021035 | |
dc.citation.issn | 2160-3308 | |
dc.citation.issue | 2 | |
dc.citation.jtitle | Physical Review X | |
dc.citation.spage | 9 | |
dc.citation.volume | 6 | |
dc.contributor.author | Nagaya, K. | |
dc.contributor.author | Motomura, K. | |
dc.contributor.author | Kukk, E. | |
dc.contributor.author | Fukuzawa, H. | |
dc.contributor.author | Wada, S. | |
dc.contributor.author | Tachibana, T. | |
dc.contributor.author | Ito, Y. | |
dc.contributor.author | Mondal, S. | |
dc.contributor.author | Sakai, T. | |
dc.contributor.author | Matsunami, K. | |
dc.contributor.author | Koga, R. | |
dc.contributor.author | Ohmura, S. | |
dc.contributor.author | Takahashi, Y. | |
dc.contributor.author | Kanno, M. | |
dc.contributor.author | Rudenko, Artem | |
dc.contributor.author | Nicolas, C. | |
dc.contributor.author | Liu, X. J. | |
dc.contributor.author | Zhang, Y. | |
dc.contributor.author | Chen, J. | |
dc.contributor.author | Anand, M. | |
dc.contributor.author | Jiang, Y. H. | |
dc.contributor.author | Kim, D. E. | |
dc.contributor.author | Tono, K. | |
dc.contributor.author | Yabashi, M. | |
dc.contributor.author | Kono, H. | |
dc.contributor.author | Miron, C. | |
dc.contributor.author | Yao, M. | |
dc.contributor.author | Ueda, K. | |
dc.contributor.authoreid | rudenko | |
dc.contributor.kstate | Rudenko, Artem | |
dc.date.accessioned | 2017-04-10T20:00:09Z | |
dc.date.available | 2017-04-10T20:00:09Z | |
dc.date.issued | 2016-06-16 | |
dc.date.published | 2016 | |
dc.description | Citation: Nagaya, K., Motomura, K., Kukk, E., Fukuzawa, H., Wada, S., Tachibana, T., . . . Ueda, K. (2016). Ultrafast Dynamics of a Nucleobase Analogue Illuminated by a Short Intense X-ray Free Electron Laser Pulse. Physical Review X, 6(2), 9. doi:10.1103/PhysRevX.6.021035 | |
dc.description.abstract | Understanding x-ray radiation damage is a crucial issue for both medical applications of x rays and x-ray free-electron-laser (XFEL) science aimed at molecular imaging. Decrypting the charge and fragmentation dynamics of nucleobases, the smallest units of a macro-biomolecule, contributes to a bottom-up understanding of the damage via cascades of phenomena following x-ray exposure. We investigate experimentally and by numerical simulations the ultrafast radiation damage induced on a nucleobase analogue (5-iodouracil) by an ultrashort (10 fs) high-intensity radiation pulse generated by XFEL at SPring-8 Angstrom Compact free electron Laser (SACLA). The present study elucidates a plausible underlying radiosensitizing mechanism of 5-iodouracil. This mechanism is independent of the exact composition of 5-iodouracil and thus relevant to other such radiosensitizers. Furthermore, we found that despite a rapid increase of the net molecular charge in the presence of iodine, and of the ultrafast release of hydrogen, the other atoms are almost frozen within the 10-fs duration of the exposure. This validates single-shot molecular imaging as a consistent approach, provided the radiation pulse used is brief enough. | |
dc.identifier.uri | http://hdl.handle.net/2097/35354 | |
dc.relation.uri | https://doi.org/10.1103/PhysRevX.6.021035 | |
dc.rights | Attribution 3.0 Unported (CC BY 3.0) | |
dc.rights.uri | https://creativecommons.org/licenses/by/3.0/ | |
dc.subject | Ionization | |
dc.subject | Charge | |
dc.subject | Molecules | |
dc.subject | Operation | |
dc.subject | Region | |
dc.subject | Atoms | |
dc.title | Ultrafast Dynamics of a Nucleobase Analogue Illuminated by a Short Intense X-ray Free Electron Laser Pulse | |
dc.type | Article |
Files
Original bundle
1 - 1 of 1