Human Food Safety Implications of Variation in Food Animal Drug Metabolism

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dc.contributor.author Lin, Zhoumeng
dc.contributor.author Vahl, Christopher I.
dc.contributor.author Riviere, Jim E.
dc.date.accessioned 2017-02-14T22:47:51Z
dc.date.available 2017-02-14T22:47:51Z
dc.identifier.uri http://hdl.handle.net/2097/35109
dc.description Citation: Lin, Z., Vahl, C. I., & Riviere, J. E. (2016). Human Food Safety Implications of Variation in Food Animal Drug Metabolism. Scientific Reports, 6. doi:10.1038/srep27907
dc.description.abstract Violative drug residues in animal-derived foods are a global food safety concern. The use of a fixed main metabolite to parent drug (M/D) ratio determined in healthy animals to establish drug tolerances and withdrawal times in diseased animals results in frequent residue violations in food-producing animals. We created a general physiologically based pharmacokinetic model for representative drugs (ceftiofur, enrofloxacin, flunixin, and sulfamethazine) in cattle and swine based on extensive published literature. Simulation results showed that the M/D ratio was not a fixed value, but a time-dependent range. Disease changed M/D ratios substantially and extended withdrawal times; these effects exhibited drug-and species-specificity. These results challenge the interpretation of violative residues based on the use of the M/D ratio to establish tolerances for metabolized drugs.
dc.relation.uri https://doi.org/10.1038/srep27907
dc.rights Attribution 4.0 International (CC BY 4.0)
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.title Human Food Safety Implications of Variation in Food Animal Drug Metabolism
dc.type Article
dc.date.published 2016
dc.citation.doi 10.1038/srep27907
dc.citation.issn 2045-2322
dc.citation.jtitle Scientific Reports
dc.citation.volume 6
dc.contributor.authoreid zhoumeng
dc.contributor.authoreid vahl
dc.contributor.authoreid jriviere
dc.contributor.kstate Lin, Zhoumeng
dc.contributor.kstate Vahl, Christopher I.
dc.contributor.kstate Riviere, Jim E.


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Attribution 4.0 International (CC BY 4.0) Except where otherwise noted, the use of this item is bound by the following: Attribution 4.0 International (CC BY 4.0)

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