Human Food Safety Implications of Variation in Food Animal Drug Metabolism

K-REx Repository

Show simple item record Lin, Zhoumeng Vahl, Christopher I. Riviere, Jim E. 2017-02-14T22:47:51Z 2017-02-14T22:47:51Z
dc.description Citation: Lin, Z., Vahl, C. I., & Riviere, J. E. (2016). Human Food Safety Implications of Variation in Food Animal Drug Metabolism. Scientific Reports, 6. doi:10.1038/srep27907
dc.description.abstract Violative drug residues in animal-derived foods are a global food safety concern. The use of a fixed main metabolite to parent drug (M/D) ratio determined in healthy animals to establish drug tolerances and withdrawal times in diseased animals results in frequent residue violations in food-producing animals. We created a general physiologically based pharmacokinetic model for representative drugs (ceftiofur, enrofloxacin, flunixin, and sulfamethazine) in cattle and swine based on extensive published literature. Simulation results showed that the M/D ratio was not a fixed value, but a time-dependent range. Disease changed M/D ratios substantially and extended withdrawal times; these effects exhibited drug-and species-specificity. These results challenge the interpretation of violative residues based on the use of the M/D ratio to establish tolerances for metabolized drugs.
dc.rights Attribution 4.0 International (CC BY 4.0)
dc.title Human Food Safety Implications of Variation in Food Animal Drug Metabolism
dc.type Article 2016
dc.citation.doi 10.1038/srep27907
dc.citation.issn 2045-2322
dc.citation.jtitle Scientific Reports
dc.citation.volume 6
dc.contributor.authoreid zhoumeng
dc.contributor.authoreid vahl
dc.contributor.authoreid jriviere
dc.contributor.kstate Lin, Zhoumeng
dc.contributor.kstate Vahl, Christopher I.
dc.contributor.kstate Riviere, Jim E.

Files in this item

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International (CC BY 4.0) Except where otherwise noted, the use of this item is bound by the following: Attribution 4.0 International (CC BY 4.0)

Search K-REx

Advanced Search


My Account


Center for the

Advancement of Digital