Acute supplementation of N-acetylcysteine does not affect muscle blood flow and oxygenation characteristics during handgrip exercise

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dc.contributor.author Smith, J. R.
dc.contributor.author Broxterman, R. M.
dc.contributor.author Ade, C. J.
dc.contributor.author Evans, K. K.
dc.contributor.author Kurti, S. P.
dc.contributor.author Hammer, S. M.
dc.contributor.author Barstow, Thomas J.
dc.contributor.author Harms, Craig A.
dc.date.accessioned 2016-09-20T17:44:54Z
dc.date.available 2016-09-20T17:44:54Z
dc.identifier.uri http://hdl.handle.net/2097/34134
dc.description Citation: Smith, J. R., Broxterman, R. M., Ade, C. J., Evans, K. K., Kurti, S. P., Hammer, S. M., . . . Harms, C. A. (2016). Acute supplementation of N-acetylcysteine does not affect muscle blood flow and oxygenation characteristics during handgrip exercise. Physiological Reports, 4(7), 1-10. doi:10.14814/phy2.12748
dc.description.abstract N-acetylcysteine (NAC; antioxidant and thiol donor) supplementation has improved exercise performance and delayed fatigue, but the underlying mechanisms are unknown. One possibility is NAC supplementation increases limb blood flow during severe-intensity exercise. The purpose was to determine if NAC supplementation affected exercising arm blood flow and muscle oxygenation characteristics. We hypothesized that NAC would lead to higher limb blood flow and lower muscle deoxygenation characteristics during severe-intensity exercise. Eight healthy nonendurance trained men (21.8 ± 1.2 years) were recruited and completed two constant power handgrip exercise tests at 80% peak power until exhaustion. Subjects orally consumed either placebo (PLA) or NAC (70 mg/kg) 60 min prior to handgrip exercise. Immediately prior to exercise, venous blood samples were collected for determination of plasma redox balance. Brachial artery blood flow (BABF) was measured via Doppler ultrasound and flexor digitorum superficialis oxygenation characteristics were measured via near-infrared spectroscopy. Following NAC supplementaiton, plasma cysteine (NAC: 47.2 ± 20.3 ?mol/L vs. PLA: 9.6 ± 1.2 ?mol/L; P = 0.001) and total cysteine (NAC: 156.2 ± 33.9 ?mol/L vs. PLA: 132.2 ± 16.3 ?mol/L; P = 0.048) increased. Time to exhaustion was not significantly different (P = 0.55) between NAC (473.0 ± 62.1 sec) and PLA (438.7 ± 58.1 sec). Resting BABF was not different (P = 0.79) with NAC (99.3 ± 31.1 mL/min) and PLA (108.3 ± 46.0 mL/min). BABF was not different (P = 0.42) during exercise or at end-exercise (NAC: 413 ± 109 mL/min; PLA: 445 ± 147 mL/min). Deoxy-[hemoglobin+myoglobin] and total-[hemoglobin+myoglobin] were not significantly different (P = 0.73 and P = 0.54, respectively) at rest or during exercise between conditions. We conclude that acute NAC supplementation does not alter oxygen delivery during exercise in men. © 2016 Published by the American Physiological Society and The Physiological Society.
dc.relation.uri https://doi.org/10.14814/phy2.12748
dc.rights Attribution 4.0 International (CC BY 4.0)
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject Blood Flow
dc.subject N -Acetylcysteine
dc.subject Vasodilation
dc.title Acute supplementation of N-acetylcysteine does not affect muscle blood flow and oxygenation characteristics during handgrip exercise
dc.type Article
dc.date.published 2016
dc.citation.doi 10.14814/phy2.12748
dc.citation.epage 10
dc.citation.issn 2051-817X
dc.citation.issue 7
dc.citation.jtitle Physiological Reports
dc.citation.spage 1
dc.citation.volume 4
dc.contributor.authoreid tbarsto
dc.contributor.authoreid caharms


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