Meta-analysis of the effects of laidlomycin propionate, fed alone or in combination with chlortetracycline, compared with monensin sodium, fed alone or in combination with tylosin, on growth performance, health, and carcass outcomes in finishing steers in North America

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dc.contributor.author Cernicchiaro, Natalia
dc.contributor.author Corbin, M.
dc.contributor.author Quinn, M.
dc.contributor.author Prouty, F.
dc.contributor.author Branine, M.
dc.contributor.author Renter, David G.
dc.date.accessioned 2016-09-20T17:34:02Z
dc.date.available 2016-09-20T17:34:02Z
dc.identifier.uri http://hdl.handle.net/2097/34058
dc.description Citation: Cernicchiaro, N., Corbin, M., Quinn, M., Prouty, F., Branine, M., & Renter, D. G. (2016). Meta-analysis of the effects of laidlomycin propionate, fed alone or in combination with chlortetracycline, compared with monensin sodium, fed alone or in combination with tylosin, on growth performance, health, and carcass outcomes in finishing steers in North America. Journal of Animal Science, 94(4), 1662-1676. doi:10.2527/jas2015-0086
dc.description.abstract The objective of this research was to use data from multiple studies to comprehensively quantify the effects of feeding 1) laidlomycin propionate (LP), alone and/or in combination with chlortetracycline, compared with 2) monensin sodium (MS), alone and/or in combination with tylosin, at commercially approved dosages, on ADG, DMI, feed efficiency (FE), mortality, and carcass characteristics (HCW and liver abscesses). A secondary objective was to explore potential sources of heterogeneity among the comparative effectiveness studies. A systematic review of peer-reviewed literature and industry reports was used to identify studies that included direct comparisons of these treatments in finishing steers in North America. Random-effects meta-analysis models of performance, carcass, and health-related outcomes were fitted with extracted data, consisting of a total of 17 data sets comprising a total of 135 pens and 13,603 steers. Results showed that pens of steers fed LP had increased ADG (live and carcass adjusted), DMI, and HCW compared with those fed monensin (P < 0.05). However, liver abscesses were more common in LP-fed cattle than in MS-fed cattle (P < 0.05), presumably because of differences in the concurrently fed antimicrobials. No significant effects (P > 0.05) were identified for FE or for health-related outcomes (overall and cause-specific mortality). There was a substantial amount of heterogeneity in outcomes among studies, and when pen size and type of production setting were included in mixed-effects metaregression models, they accounted for only a small proportion of the between-study heterogeneity found in the meta-analysis models. Therefore, caution should be exercised when interpreting summary estimates in the presence of substantial heterogeneity. However, these results provide comprehensive information on the comparative effects of different ionophores across multiple studies and multiple years, states, and production settings. These unique results can enable quantitative and informed decisions by potential end users of these feed additives that are widely used in the U.S. beef industry for reducing the costs of beef production through enhanced cattle performance.
dc.relation.uri https://doi.org/10.2527/jas2015-0086
dc.rights Copyright © 2016. American Society of Animal Science.
dc.rights.uri http://www.sherpa.ac.uk/romeo/issn/0021-8812/
dc.subject Feedlot Performance
dc.subject Finishing Steers
dc.subject Ionophore
dc.subject Laidlomycin
dc.subject Propionate
dc.subject Meta-Analysis
dc.title Meta-analysis of the effects of laidlomycin propionate, fed alone or in combination with chlortetracycline, compared with monensin sodium, fed alone or in combination with tylosin, on growth performance, health, and carcass outcomes in finishing steers in North America
dc.type Article
dc.date.published 2016
dc.citation.doi 10.2527/jas2015-0086
dc.citation.epage 1676
dc.citation.issn 0021-8812
dc.citation.issue 4
dc.citation.jtitle Journal of Animal Science
dc.citation.spage 1662
dc.citation.volume 94
dc.description.embargo 2017-06
dc.contributor.authoreid ncernic
dc.contributor.authoreid drenter


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