Transmission of scrapie prions to primate after an extended silent incubation period

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dc.contributor.author Comoy, E. E.
dc.contributor.author Mikol, J.
dc.contributor.author Luccantoni-Freire, S.
dc.contributor.author Correia, E.
dc.contributor.author Lescoutra-Etchegaray, N.
dc.contributor.author Durand, V.
dc.contributor.author Dehen, C.
dc.contributor.author Andreoletti, O.
dc.contributor.author Casalone, C.
dc.contributor.author Richt, Juergen A.
dc.contributor.author Greenlee, J. J.
dc.contributor.author Baron, T.
dc.contributor.author Benestad, S. L.
dc.contributor.author Brown, P.
dc.contributor.author Deslys, J. P.
dc.date.accessioned 2016-04-04T22:45:10Z
dc.date.available 2016-04-04T22:45:10Z
dc.identifier.uri http://hdl.handle.net/2097/32296
dc.description Citation: Comoy, E. E., Mikol, J., Luccantoni-Freire, S., Correia, E., Lescoutra-Etchegaray, N., Durand, V., . . . Deslys, J. P. (2015). Transmission of scrapie prions to primate after an extended silent incubation period. Scientific Reports, 5. doi:10.1038/srep11573
dc.description Classical bovine spongiform encephalopathy (c-BSE) is the only animal prion disease reputed to be zoonotic, causing variant Creutzfeldt-Jakob disease (vCJD) in humans and having guided protective measures for animal and human health against animal prion diseases. Recently, partial transmissions to humanized mice showed that the zoonotic potential of scrapie might be similar to c-BSE. We here report the direct transmission of a natural classical scrapie isolate to cynomolgus macaque, a highly relevant model for human prion diseases, after a 10-year silent incubation period, with features similar to those reported for human cases of sporadic CJD. Scrapie is thus actually transmissible to primates with incubation periods compatible with their life expectancy, although fourfold longer than BSE. Long-term experimental transmission studies are necessary to better assess the zoonotic potential of other prion diseases with high prevalence, notably Chronic Wasting Disease of deer and elk and atypical/Nor98 scrapie.
dc.relation.uri https://doi.org/10.1038/srep11573
dc.rights Attribution 4.0 International (CC BY 4.0)
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Transmission of scrapie prions to primate after an extended silent incubation period
dc.type Article
dc.date.published 2015
dc.citation.doi 10.1038/srep11573
dc.citation.issn 2045-2322
dc.citation.jtitle Scientific Reports
dc.citation.volume 5
dc.contributor.authoreid jricht


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