Transmission of scrapie prions to primate after an extended silent incubation period

dc.citation.doi10.1038/srep11573
dc.citation.issn2045-2322
dc.citation.jtitleScientific Reports
dc.citation.volume5
dc.contributor.authorComoy, E. E.
dc.contributor.authorMikol, J.
dc.contributor.authorLuccantoni-Freire, S.
dc.contributor.authorCorreia, E.
dc.contributor.authorLescoutra-Etchegaray, N.
dc.contributor.authorDurand, V.
dc.contributor.authorDehen, C.
dc.contributor.authorAndreoletti, O.
dc.contributor.authorCasalone, C.
dc.contributor.authorRicht, Juergen A.
dc.contributor.authorGreenlee, J. J.
dc.contributor.authorBaron, T.
dc.contributor.authorBenestad, S. L.
dc.contributor.authorBrown, P.
dc.contributor.authorDeslys, J. P.
dc.contributor.authoreidjricht
dc.date.accessioned2016-04-04T22:45:10Z
dc.date.available2016-04-04T22:45:10Z
dc.date.issued2015-06-30
dc.date.published2015
dc.descriptionCitation: Comoy, E. E., Mikol, J., Luccantoni-Freire, S., Correia, E., Lescoutra-Etchegaray, N., Durand, V., . . . Deslys, J. P. (2015). Transmission of scrapie prions to primate after an extended silent incubation period. Scientific Reports, 5. doi:10.1038/srep11573
dc.descriptionClassical bovine spongiform encephalopathy (c-BSE) is the only animal prion disease reputed to be zoonotic, causing variant Creutzfeldt-Jakob disease (vCJD) in humans and having guided protective measures for animal and human health against animal prion diseases. Recently, partial transmissions to humanized mice showed that the zoonotic potential of scrapie might be similar to c-BSE. We here report the direct transmission of a natural classical scrapie isolate to cynomolgus macaque, a highly relevant model for human prion diseases, after a 10-year silent incubation period, with features similar to those reported for human cases of sporadic CJD. Scrapie is thus actually transmissible to primates with incubation periods compatible with their life expectancy, although fourfold longer than BSE. Long-term experimental transmission studies are necessary to better assess the zoonotic potential of other prion diseases with high prevalence, notably Chronic Wasting Disease of deer and elk and atypical/Nor98 scrapie.
dc.identifier.urihttp://hdl.handle.net/2097/32296
dc.relation.urihttps://doi.org/10.1038/srep11573
dc.rightsAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleTransmission of scrapie prions to primate after an extended silent incubation period
dc.typeArticle

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