Are the health attributes of lycopene related to its antioxidant function?

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dc.contributor.author Erdman, John W. Jr.
dc.contributor.author Ford, Nikki A.
dc.contributor.author Lindshield, Brian L.
dc.date.accessioned 2009-03-31T19:53:57Z
dc.date.available 2009-03-31T19:53:57Z
dc.date.issued 2009-03-31T19:53:57Z
dc.identifier.uri http://hdl.handle.net/2097/1308
dc.description.abstract A variety of epidemiological trials have suggested that higher intake of lycopene-containing foods (primarily tomato products) or blood lycopene concentrations are associated with decreased cardiovascular disease and prostate cancer risk. Of the carotenoids tested, lycopene has been demonstrated to be the most potent in vitro antioxidant leading many researchers to conclude that the antioxidant properties of lycopene are responsible for disease prevention. In our review of human and animal trials with lycopene, or lycopene-containing extracts, there is limited support for the in vivo antioxidant function for lycopene. Moreover, tissue levels of lycopene appear to be too low to play a meaningful antioxidant role. We conclude that there is an overall shortage of supportive evidence for the "antioxidant hypothesis" as lycopene's major in vivo mechanism of action. Our laboratory has postulated that metabolic products of lycopene, the lycopenoids, may be responsible for some of lycopene's reported bioactivity. en
dc.relation.uri http://www.elsevier.com/wps/find/journaldescription.cws_home/622787/description#description en
dc.subject Lycopene en
dc.subject Lycopenoids en
dc.subject Carotenoids en
dc.subject Antioxidant en
dc.subject Prostate cancer en
dc.subject Oxidative stress en
dc.subject Cardiovascular disease
dc.subject Vitamin E
dc.subject Mechanism
dc.title Are the health attributes of lycopene related to its antioxidant function? en
dc.type Article (author version) en
dc.date.published 2009 en
dc.citation.doi doi:10.1016/j.abb.2008.10.022 en
dc.citation.epage 235 en
dc.citation.issue 2 en
dc.citation.jtitle Archives of biochemistry and biophysics en
dc.citation.spage 229 en
dc.citation.volume 483 en
dc.contributor.authoreid blindsh en


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