Grape exosome-like nanoparticles, a novel inducer of intestinal stem cells, protect mice against DSS induced colitis
dc.citation.doi | doi:10.1038/mt.2013.64 | en_US |
dc.citation.epage | 1357 | en_US |
dc.citation.issue | 7 | en_US |
dc.citation.jtitle | Molecular Therapy | en_US |
dc.citation.spage | 1345 | en_US |
dc.citation.volume | 21 | en_US |
dc.contributor.author | Ju, Songwen | |
dc.contributor.author | Mu, Jingyao | |
dc.contributor.author | Dokland, Terje | |
dc.contributor.author | Zhuang, Xiaoying | |
dc.contributor.author | Wang, Qilong | |
dc.contributor.author | Jiang, Hong | |
dc.contributor.author | Xiang, Xiaoyu | |
dc.contributor.author | Deng, Zhong-Bin | |
dc.contributor.author | Wang, Baomei | |
dc.contributor.author | Zhang, Lifeng | |
dc.contributor.author | Roth, Mary R. | |
dc.contributor.author | Welti, Ruth | |
dc.contributor.author | Mobley, James | |
dc.contributor.author | Jun, Yan | |
dc.contributor.author | Miller, Donald | |
dc.contributor.author | Zhang, Huang-Ge | |
dc.contributor.authoreid | mrroth | en_US |
dc.contributor.authoreid | welti | en_US |
dc.date.accessioned | 2013-08-26T19:24:59Z | |
dc.date.available | 2013-08-26T19:24:59Z | |
dc.date.issued | 2013-08-26 | |
dc.date.published | 2013 | en_US |
dc.description.abstract | Food derived exosome-like nanoparticles pass through the intestinal tract throughout our lives, but little is known about their impact or function. Here, as a proof of concept, we show that the cells targeted by grape exosome-like nanoparticles (GELNs) are intestinal stem cells whose responses underlie the GELN-mediated intestinal tissue remodeling and protection against dextran sulfate sodium (DSS) induced colitis. This finding is further supported by the fact that co-culturing of crypt or sorted Lgr5+ stem cells with GELNs markedly improved organoid formation. GELN lipids play a role in induction of Lgr5+ stem cells, and the liposome-like nanoparticles (LLNs) assembled with lipids from GELNs are required for in vivo targeting of intestinal stem cells. Blocking β-catenin mediated signaling pathways of GELN recipient cells attenuates the production of Lgr5+ stem cells. Thus, GELNs not only modulate intestinal tissue renewal processes, but can participate in the remodeling of it in response to pathological triggers. | en_US |
dc.identifier.uri | http://hdl.handle.net/2097/16363 | |
dc.language.iso | en_US | en_US |
dc.relation.uri | http://www.nature.com/mt/journal/v21/n7/full/mt201364a.html | en_US |
dc.subject | Grape exosome-like nanoparticles | en_US |
dc.subject | Exosomes | en_US |
dc.subject | Lipids | en_US |
dc.subject | Intestinal stem cell | en_US |
dc.subject | Wnt/β-catenin pathway | en_US |
dc.title | Grape exosome-like nanoparticles, a novel inducer of intestinal stem cells, protect mice against DSS induced colitis | en_US |
dc.title.alternative | Grape exosome-like nanoparticles induce intestinal stem cells and protect mice from DSS-induced colitis | en_US |
dc.type | Article (author version) | en_US |