Cebula, AlanGilland, DavidSu, Li-MingWagenaar, DouglasBahadori, Amir A.2016-10-202016-10-202011-09-15http://hdl.handle.net/2097/34456Citation: Proc. SPIE 8143, Medical Applications of Radiation Detectors, 814305 (September 14, 2011); doi:10.1117/12.896235The objective of this work is to develop an improved SPECT camera for dedicated prostate imaging. Complementing the recent advancements in agents for molecular prostate imaging, this device has the potential to assist in distinguishing benign from aggressive cancers, to improve site-specific localization of cancer, to improve accuracy of needle-guided prostate biopsy of cancer sites, and to aid in focal therapy procedures such as cryotherapy and radiation. Theoretical calculations show that the spatial resolution/detection sensitivity of the proposed SPECT camera can rival or exceed 3D PET and further signal-to-noise advantage is attained with the better energy resolution of the CZT modules. Based on photon transport simulation studies, the system has a reconstructed spatial resolution of 4.8 mm with a sensitivity of 0.0001. Reconstruction of a simulated prostate distribution demonstrates the focal imaging capability of the system.en-USThis Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).Single Photon Emission Computed Tomography (SPECT)Prostate Imaging, Cadmium Zinc Telluride (CZT)Article (publisher version)