Loughmiller, J.A.De La Llata, M.Moser, S.Musser, R.E.Stott, R.D.Tokach, Michael D.Nelssen, Jim L.Goodband, Robert D.Dritz, Steven S.2010-02-192010-02-192010-02-19http://hdl.handle.net/2097/2702Thirty-five growing pigs (initially 65 ± 2 lb) were used in a metabolism study to determine the effects of a single enteric disease challenge on N retention, growth performance, and blood immunological variables. Twenty-one pigs were challenged with Salmonella typhimurium, and six pigs were assigned to an ad libitum-fed, nonchallenged control group. Eight additional nonchallenged pigs were pair-fed the feed intake of an S. typhimurium challenged counterpart. There were five 4 d collection periods (d 4 to 7, d 8 to 11, d 12 to 15, d 16 to 19, and d 22 to 25), with the S. typhimurium challenge occurring on d 8. Serum haptoglobin concentration increased in the diseasechallenged pigs, when compared to both nonchallenged treatments Growth performance and N retention were decreased temporarily during the immune challenge period but recovered to levels similar to those of nonchallenged control pigs by the end ofthe experiment on d 25. These results suggest that a single acute disease challenge may not be accompanied by large compromises in grow1h performance and lean growth rate.SwineGrowing pigsNitrogen retentionDisease challengeConference paper