Smith, Connor2022-08-172022-08-172022https://hdl.handle.net/2097/42476The concept of mathematical modeling to develop a digital twin of biological processes is in a nascent state. Despite the limited understanding of many biological pathways, a well-trained mathematical model can successfully conduct many experiments to guide development more efficiently. The Organ On a Chip (OOC) concept is a feat of engineering and biology where organs can be simulated in vitro for drug discovery, toxicology, and pharmacokinetic/pharmacodynamic (PK/PD) studies. My Master’s Report aims to conduct a literature review on OOCs and the kinetics of the biological pathways in the liver related to Non-alcoholic Fatty Liver Disease (NAFLD). The findings will be applied to develop a data-assisted mathematical modeling framework. A liver OOC for NAFLD is used as the base model where the kinetics of the reactions of metabolites, substrates, and drugs are simulated. A hybrid modeling approach combining first-principle-based models, PK/PD, and machine learning will enable a better understanding of factors impacting NAFLD.en-US© the author. This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).http://rightsstatements.org/vocab/InC/1.0/Mathematical modelingOrgan on a chipReport