Canapp, Sherman O. Jr.2022-06-172022-06-171999https://hdl.handle.net/2097/42332Objective-To evaluate the effects of orally administered glucosamine hydrochloride (GIAm}-chondroitin sulfate (CS) and GIAm-CS-S-adenosyl-L-methionine (SAMe) on chemically induced synovitis in the radiocarpal joint of dogs. Animals-32 adult mixed-breed dogs. Procedure-For 21 days, all dogs received a sham capsule (3 groups) or GIAm-CS (prior treatment group) in a double-blinded study. Unilateral carpal synovitis then was induced by injecting the right radiocarpal joint with chymopapain, and the left radiocarpal joint (control joint) with saline (0.9% NaCl) solution. Joints were injected on alternate days for 3 injections. After induction of synovitis, 2 groups receiving sham treatment were given GIAm-CS or GIAm-CS-SAMe. The fourth group continued to receive sham capsules (control group). Joint inflammation was quantified, using nuclear scintigraphy (before injection of joints and days 13, 20, 27, 34, 41, and 48 after injection). Lameness evaluations were performed daily. Results-Dogs given GIAm-CS before induction of synovitis had significantly less scintigraphic activity in the soft-tissue phase 48 days after joint injection, had significantly less uptake in the bone phase 41 and 48 days after joint injection, and had significantly lower lameness scores on days 12 to 19, 23, and 24 after injection, compared with other groups. Conclusions and Clinical Relevancer--Analysis of results of this study suggest that prior treatment with GIAm-CS for 21 days had a protective effect against chemically induced synovitis and associated bone remodeling. Prior treatment with GIAm-CS also reduced lameness in dogs with induced synovitis.en-USThis Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).https://rightsstatements.org/vocab/InC/1.0/Thesis