Coffin, Morgan J.Majarin, RodrigoMumm, Jared M.Bortoluzzi, Eduarda M.Ruiz, Luke A.Tommerdahl, MarkHolden, Jameson K.Walilko, TimZai, LailaHulbert, Lindsey E.2019-07-312019-07-312017-12-08http://hdl.handle.net/2097/39865Agricultural and clinical research communities seek objective tools to detect and track prepathological states for prevention, disease-treatment, and therapeutics. We propose a novel, quantitative approach to test the functional state of the somatosensory system and detect aberrations in neurophysiology associated with prepathological injury or sickness. Leveraging the evolutionarily preserved concepts of lateral inhibition and parallel processing, the human version of this approach can detect the slightest changes in brain health. However, an animal model is needed to benefit and translate results to both agriculture and clinical researchers. The objective of this study was to refine methodologies for the use of tactile stimulation (TS; vibration at 75 Hz for 1 s; Porcine Brain Gauge; Cortical Metrics, North Carolina) to condition and test a pigs ability to associate right-TS with a right-ball and left-TS with a left-toy during 12 tests (right and left tested every test). Minipigs (n = 8; boars = 7 gilt = 1; NSRRC, Columbia, MO) were used to determine the effects of: 1) placement of two TS-devices (sides or behind ears); 2) right- or left-bowl bias, time (1000 h or 0300 h) and; 3) day (6 test consecutive days). Pig with ear-placement spent more time at the correct bowl than pigs with side-placement (P = 0.05). All pigs spent more time (P = 0.02) in the correct-bowl area and tended to have a greater correct-index (P = 0.09) if the first test administered was on the right than when the test started on the left. Pigs tended (P = 0.06) to spend less time making a decision and spent more time at the correct bowl (P < 0.01) in the morning tests than evening tests. In addition, all pigs spent less time at the correct bowl and decreased correct frequency after each day (P < 0.05). Future studies will be designed to repeat tests for side-bias and take place in the mornings, after feeding. The effects of day suggest that pigs became bored over time, therefore, future experiments will include more operant-conditioned tasks to test motivation, and physical barriers to restrict movement after the subject enters the right- or left-bowl area.en-USThis Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).Fall 2017Text