Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors

Prior, Allan M.Kim, YunjeongWeerasekara, SahaniMoroze, MeghanAlliston, Kevin R.Uy, Roxanne Adeline Z.Groutas, William C.Chang, Kyeong-OkHua, Duy H.2014-02-212014-02-212013-12-01http://hdl.handle.net/2097/17181A class of tripeptidyl transition state inhibitors containing a P1 glutamine surrogate, a P2 leucine, and a P3 arylalanines, was found to potently inhibit Norwalk virus replication in enzyme and cell based assays. An array of warheads, including aldehyde, α-ketoamide, bisulfite adduct, and α-hydroxyphosphonate transition state mimic, was also investigated. Tripeptidyls 2 and 6 possess antiviral activities against noroviruses, human rhinovirus, severe acute respiratory syndrome coronavirus, and coronavirus 229E, suggesting a broad range of antiviral activities.en-USThis Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).Viral 3C and 3C-like protease inhibitorsNorovirusHuman rhinovirusSevere acute respiratory syndrome coronavirusConronavirus 229EDesign, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitorsArticle (author version)