Serum Metabolomic Profiling of Piglets Infected with Virulent Classical Swine Fever Virus

dc.citationGong, W. J., Jia, J. J., Zhang, B. K., Mi, S. J., Zhang, L., Xie, X. M., . . . Tu, C. C. (2017). Serum Metabolomic Profiling of Piglets Infected with Virulent Classical Swine Fever Virus. Frontiers in Microbiology, 8, 14. doi.org/10.3389/fmicb.2017.00731
dc.citation.doi10.3389/fmicb.2017.00731
dc.citation.issn1664-302X
dc.citation.jtitleFrontiers in Microbiology
dc.citation.spage14
dc.citation.volume8
dc.contributor.authorGong, Wenjie J.
dc.contributor.authorJia, J. J.
dc.contributor.authorZhang, B. K.
dc.contributor.authorMi, S. J.
dc.contributor.authorZhang, L.
dc.contributor.authorXie, X. M.
dc.contributor.authorGuo, H. C.
dc.contributor.authorShi, Jishu
dc.contributor.authorTu, C. C.
dc.contributor.authoreidjshi
dc.contributor.kstateShi, Jishu
dc.date.accessioned2017-11-30T21:38:31Z
dc.date.available2017-11-30T21:38:31Z
dc.date.issued2017-04-27
dc.date.published2017
dc.descriptionCitation: Gong, W. J., Jia, J. J., Zhang, B. K., Mi, S. J., Zhang, L., Xie, X. M., . . . Tu, C. C. (2017). Serum Metabolomic Profiling of Piglets Infected with Virulent Classical Swine Fever Virus. Frontiers in Microbiology, 8, 14. doi:10.3389/fmicb.2017.00731
dc.description.abstractClassical swine fever (CSF) is a highly contagious swine infectious disease and causes significant economic losses for the pig industry worldwide. The objective of this study was to determine whether small molecule metabolites contribute to the pathogenesis of CSF. Birefly, serum metabolomics of CSFV Shimen strain-infected piglets were analyzed by ultraperformance liquid chromatography/electrospray ionization time-of-flight mass spectrometry (UPLC/ESI-Q-TOF/MS) in combination with multivariate statistical analysis. In CSFV-infected piglets at days 3 and 7 post-infection changes were found in metabolites associated with several key metabolic pathways, including tryptophan catabolism and the kynurenine pathway, phenylalanine metabolism, fatty acid and lipid metabolism, the tricarboxylic acid and urea cycles, branched-chain amino acid metabolism, and nucleotide metabolism. Several pathways involved in energy metabolism including fatty acid biosynthesis and beta-oxidation, branched-chain amino acid metabolism, and the tricarboxylic acid cycle were significantly inhibited. Changes were also observed in several metabolites exclusively associated with gut microbiota. The metabolomic profiles indicate that CSFV-host gut microbiome interactions play a role in the development of CSF.
dc.identifier.urihttp://hdl.handle.net/2097/38285
dc.relation.urihttps://doi.org/10.3389/fmicb.2017.00731
dc.rightsAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectMetabolomic Profiling
dc.subjectUplc-Ms
dc.subjectCsfv
dc.subjectMetabolite
dc.subjectHepatitis-C Virus
dc.subjectFatty-Acid Synthase
dc.titleSerum Metabolomic Profiling of Piglets Infected with Virulent Classical Swine Fever Virus
dc.typeArticle

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
fmicb-08-00731.pdf
Size:
3.65 MB
Format:
Adobe Portable Document Format