Sex-specific post-translational regulation of the gamete fusogen GCS1 in the isogamous volvocine alga Gonium pectorale

dc.citation.doidoi:10.1128/EC.00330-13en_US
dc.citation.epage656en_US
dc.citation.issue5en_US
dc.citation.jtitleEukaryotic Cellen_US
dc.citation.spage648en_US
dc.citation.volume13en_US
dc.contributor.authorKawai-Toyooka, Hiroko
dc.contributor.authorMori, Toshiyuki
dc.contributor.authorHamaji, Takashi
dc.contributor.authorSuzuki, Masahiro
dc.contributor.authorOlson, Bradley J.
dc.contributor.authorUemura, Tomohiro
dc.contributor.authorUeda, Takashi
dc.contributor.authorNakano, Akihiko
dc.contributor.authorToyoda, Atsushi
dc.contributor.authorFujiyama, Asao
dc.contributor.authorNozaki, Hisayoshi
dc.contributor.authoreidbjscoen_US
dc.date.accessioned2014-07-22T13:56:29Z
dc.date.available2014-07-22T13:56:29Z
dc.date.issued2014-07-22
dc.date.published2014en_US
dc.description.abstractMale and female, generally defined based on differences in gamete size and motility, likely have multiple independent origins, appearing to have evolved from isogamous organisms in various eukaryotic lineages. Recent studies of the gamete fusogen GCS1/HAP2 indicate that this protein is deeply conserved across eukaryotes, and its exclusive and/or functional expression generally resides in males or in male homologues. However, little is known regarding the conserved or primitive molecular traits of males and females within eukaryotes. Here, using morphologically indistinguishable isogametes of the colonial volvocine Gonium pectorale, we demonstrated that GCS1 is differently regulated between the sexes. G. pectorale GCS1 molecules in one sex (homologous to “male”) are transported from the gamete cytoplasm to the protruded fusion site, whereas those of the other sex (“females”) are quickly degraded within the cytoplasm upon gamete activation. This molecular trait difference might be conserved across various eukaryotic lineages and may represent male and female prototypes originating from a common eukaryotic ancestor.en_US
dc.identifier.urihttp://hdl.handle.net/2097/18121
dc.language.isoen_USen_US
dc.relation.urihttp://ec.asm.org/content/13/5/648en_US
dc.subjectGamete fusogen GCS1/HAP2en_US
dc.subjectEukaryotesen_US
dc.subjectIsogametesen_US
dc.subjectGonium pectoraleen_US
dc.subjectGCS1en_US
dc.titleSex-specific post-translational regulation of the gamete fusogen GCS1 in the isogamous volvocine alga Gonium pectoraleen_US
dc.typeArticle (author version)en_US

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