A/C magnetic hyperthermia of melanoma mediated by iron(0)/iron oxide core/shell magnetic nanoparticles : a mouse study
dc.contributor.author | Balivada, Sivasai | |
dc.date.accessioned | 2009-12-14T16:59:20Z | |
dc.date.available | 2009-12-14T16:59:20Z | |
dc.date.graduationmonth | December | en_US |
dc.date.issued | 2009-12-14T16:59:20Z | |
dc.date.published | 2009 | en_US |
dc.description.abstract | There is renewed interest in magnetic hyperthermia as a treatment modality for cancer, especially when it is combined with other more traditional therapeutic approaches, such as the co-delivery of anticancer drugs or photodynamic therapy. The influence of bimagnetic nanoparticles (MNPs) combined with short external alternating magnetic field (AMF) exposure on the growth of subcutaneous mouse melanomas (B16-F10) was evaluated. Bimagnetic Fe/Fe3O4 core/shell nanoparticles were designed for cancer targeting after intratumoral or intravenous administration. Their inorganic center was protected against rapid biocorrosion by organic dopamine-oligoethylene glycol ligands. TCPP (4-tetracarboxyphenyl porphyrin) units were attached to the dopamine-oligoethylene glycol ligands. The magnetic hyperthermia results obtained after intratumoral injection indicated that micromolar concentrations of iron given within the modified core-shell Fe/Fe3O4 nanoparticles caused a significant anti-tumor effect on murine B16-F10 melanoma with three short 10-minute AMF exposures. There is a decrease in tumor size after intravenous administration of the MNPs followed by three consecutive days of AMF exposure. These results indicate that intratumoral administration of surface-modified MNPs can attenuate mouse melanoma after AMF exposure. Moreover, intravenous administration of these MNPs followed by AMF exposure attenuates melanomas, indicating that adequate amounts of TCPP-labeled stealth Fe/Fe3O4 nanoparticles can accumulate in murine melanoma after systemic delivery to allow effective magnetic hyperthermic therapy in a rodent tumor mode. | en_US |
dc.description.advisor | Deryl L. Troyer | en_US |
dc.description.degree | Master of Science | en_US |
dc.description.department | Department of Anatomy and Physiology | en_US |
dc.description.level | Masters | en_US |
dc.description.sponsorship | National Institutes of Health (NIH); National Science Foundation(NSF); Small Business Innovation Research(SBIR) | en_US |
dc.identifier.uri | http://hdl.handle.net/2097/2282 | |
dc.language.iso | en_US | en_US |
dc.publisher | Kansas State University | en |
dc.subject | Magnetic hyperthermia | en_US |
dc.subject | Melanoma | en_US |
dc.subject | cancer | en_US |
dc.subject | Magnetic nanoparticles | en_US |
dc.subject.umi | Health Sciences, Medicine and Surgery (0564) | en_US |
dc.subject.umi | Health Sciences, Oncology (0992) | en_US |
dc.title | A/C magnetic hyperthermia of melanoma mediated by iron(0)/iron oxide core/shell magnetic nanoparticles : a mouse study | en_US |
dc.title.alternative | AC magnetic hyperthermia of melanoma mediated by iron(0)/iron oxide core/shell magnetic nanoparticles | |
dc.type | Thesis | en_US |