In depth investigation of Branched Amphipathic Peptide Capsules (BAPCs) for enhanced mRNA transfection efficiency
| dc.contributor.author | Yoon, Sungmin | |
| dc.date.accessioned | 2024-04-11T20:25:59Z | |
| dc.date.graduationmonth | May | |
| dc.date.issued | 2024 | |
| dc.description.abstract | This study developed new strategies to improve the delivery potential of two peptide delivery systems: branched amphiphilic peptide capsules (BAPC) and aqueous partitioning capsules (APC). The parameters investigated included transfection efficiency, endosomal escape and temporal stability. Sequence modifications to the parent sequences were investigated. Biophysical characterizations and cell biological studies were employed. Modified sequences were identified that enhanced the performance of the two capsule types. | |
| dc.description.advisor | John M. Tomich | |
| dc.description.degree | Doctor of Philosophy | |
| dc.description.department | Biochemistry and Molecular Biophysics Interdepartmental Program | |
| dc.description.level | Doctoral | |
| dc.identifier.uri | https://hdl.handle.net/2097/44228 | |
| dc.language.iso | en_US | |
| dc.publisher | Kansas State University | |
| dc.rights | © the author. This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). | |
| dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | |
| dc.subject | Nanotechnology | |
| dc.subject | Gene delivery | |
| dc.subject | Peptide vector | |
| dc.subject | BAPC | |
| dc.subject | APC | |
| dc.title | In depth investigation of Branched Amphipathic Peptide Capsules (BAPCs) for enhanced mRNA transfection efficiency | |
| dc.type | Dissertation | |
| local.embargo.terms | 2025-04-11 |
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