1.15 Å resolution structure of the proteasome-assembly chaperone Nas2 PDZ domain
| dc.citation.doi | doi:10.1107/S2053230X14003884 | en_US |
| dc.citation.epage | 423 | en_US |
| dc.citation.issue | 4 | en_US |
| dc.citation.jtitle | Acta Crystallographica.Section F, Structural Biology Communications | en_US |
| dc.citation.spage | 418 | en_US |
| dc.citation.volume | 70 | en_US |
| dc.contributor.author | Singh, Chingakham R. | |
| dc.contributor.author | Lovell, Scott | |
| dc.contributor.author | Mehzabeen, Nurjahan | |
| dc.contributor.author | Chowdhury, Wasimul Q. | |
| dc.contributor.author | Geanes, Eric S. | |
| dc.contributor.author | Battaile, Kevin P. | |
| dc.contributor.author | Roelofs, Jeroen | |
| dc.contributor.authoreid | csingh | en_US |
| dc.contributor.authoreid | jroelofs | en_US |
| dc.date.accessioned | 2014-05-28T21:33:56Z | |
| dc.date.available | 2014-05-28T21:33:56Z | |
| dc.date.issued | 2014-05-28 | |
| dc.date.published | 2014 | en_US |
| dc.description.abstract | The 26S proteasome is a 2.5 MDa protease dedicated to the degradation of ubiquitinated proteins in eukaryotes. The assembly of this complex containing 66 polypeptides is assisted by at least nine proteasome-specific chaperones. One of these, Nas2, binds to the proteasomal AAA-ATPase subunit Rpt5. The PDZ domain of Nas2 binds to the C-terminal tail of Rpt5; however, it does not require the C-terminus of Rpt5 for binding. Here, the 1.15 Å resolution structure of the PDZ domain of Nas2 is reported. This structure will provide a basis for further insights regarding the structure and function of Nas2 in proteasome assembly. | en_US |
| dc.identifier.uri | http://hdl.handle.net/2097/17799 | |
| dc.language.iso | en_US | en_US |
| dc.relation.uri | http://scripts.iucr.org/cgi-bin/paper?S2053230X14003884 | en_US |
| dc.rights | This open-access article is distributed under the terms of the Creative Commons Attribution Licence http://creativecommons.org/licenses/by/2.0/uk/legalcode, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. | en_US |
| dc.subject | 26S proteasome | en_US |
| dc.subject | Proteasome-assembly | en_US |
| dc.subject | Nas2 PDZ domain | en_US |
| dc.title | 1.15 Å resolution structure of the proteasome-assembly chaperone Nas2 PDZ domain | en_US |
| dc.type | Article (publisher version) | en_US |
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