The effects of flunixin meglumine on viral shedding in calves
dc.contributor.author | Neyland, Trey Neyland | |
dc.date.accessioned | 2025-04-15T18:14:25Z | |
dc.date.available | 2025-04-15T18:14:25Z | |
dc.date.graduationmonth | May | |
dc.date.issued | 2025 | |
dc.description.abstract | Background – The effects of a Food and Drug Administration approved non-steroidal anti-inflammatory (NSAID) on viral shedding in cattle has not been investigated. Hypothesis/Objective - The hypothesis of this study was that flunixin meglumine would increase the magnitude and duration of viral shedding in calves inoculated with bovine herpesvirus-1 (BHV-1). Another objective was to investigate the consistency of BHV-1 shedding in inoculated calves. Animals - Twelve Holstein cross-bred steer calves, BHV-1 PCR-negative. Methods – In this randomized-control study, calves were randomized into treatment (FM) and control (CON) groups. All calves were inoculated intranasally with approximately 4-mLs of 1x105 TCID50 of BHV-1. Nasal swabs for BHV-1 PCR testing were collected every 24 hours following inoculation. Calves in the FM group were treated with 2.2mg/kg of flunixin meglumine intravenously after the first BHV-1 PCR positive sample. Magnitude and duration of viral shedding between groups was compared, and a p-value of <0.05 was considered significant. Results - The least square mean of the BHV-1 total log10 AUC of the FM group was 6.11 (95% CI: 4.62-7.60) and CON group was 7.49 (95% CI: 6.00-8.98). The FM group's mean duration from initial to last positive BHV-1 PCR was 7.33 days (Range: 3-12, SD: 4.41), and the CON group's mean was 9.5 days (Range: 1-17, SD: 5.80). There was a treatment-by-time interaction, and there was no difference in BHV-1 shedding by treatment group when comparing mean log10 TDIC50. Conclusions and Clinical Importance – Intranasal inoculation with BHV-1 had a wide range of shedding magnitude and duration. Flunixin meglumine administration in BHV-1 challenged calves did not result in an increase in magnitude or duration of viral shedding. | |
dc.description.advisor | Michael D. Apley | |
dc.description.degree | Master of Science in Biomedical Sciences | |
dc.description.department | Department of Clinical Sciences | |
dc.description.level | Masters | |
dc.description.sponsorship | Kansas State University College of Veterinary Medicine Mentor Clinical, Applied, or. Translational Research Intramural Grant | |
dc.identifier.uri | https://hdl.handle.net/2097/44906 | |
dc.subject | Non-steroidal anti-inflammatory | |
dc.subject | flunixin meglumine | |
dc.subject | viral shedding | |
dc.title | The effects of flunixin meglumine on viral shedding in calves | |
dc.type | Thesis |