The effects of flunixin meglumine on viral shedding in calves

dc.contributor.authorNeyland, Trey Neyland
dc.date.accessioned2025-04-15T18:14:25Z
dc.date.available2025-04-15T18:14:25Z
dc.date.graduationmonthMay
dc.date.issued2025
dc.description.abstractBackground – The effects of a Food and Drug Administration approved non-steroidal anti-inflammatory (NSAID) on viral shedding in cattle has not been investigated. Hypothesis/Objective - The hypothesis of this study was that flunixin meglumine would increase the magnitude and duration of viral shedding in calves inoculated with bovine herpesvirus-1 (BHV-1). Another objective was to investigate the consistency of BHV-1 shedding in inoculated calves. Animals - Twelve Holstein cross-bred steer calves, BHV-1 PCR-negative. Methods – In this randomized-control study, calves were randomized into treatment (FM) and control (CON) groups. All calves were inoculated intranasally with approximately 4-mLs of 1x105 TCID50 of BHV-1. Nasal swabs for BHV-1 PCR testing were collected every 24 hours following inoculation. Calves in the FM group were treated with 2.2mg/kg of flunixin meglumine intravenously after the first BHV-1 PCR positive sample. Magnitude and duration of viral shedding between groups was compared, and a p-value of <0.05 was considered significant. Results - The least square mean of the BHV-1 total log10 AUC of the FM group was 6.11 (95% CI: 4.62-7.60) and CON group was 7.49 (95% CI: 6.00-8.98). The FM group's mean duration from initial to last positive BHV-1 PCR was 7.33 days (Range: 3-12, SD: 4.41), and the CON group's mean was 9.5 days (Range: 1-17, SD: 5.80). There was a treatment-by-time interaction, and there was no difference in BHV-1 shedding by treatment group when comparing mean log10 TDIC50. Conclusions and Clinical Importance – Intranasal inoculation with BHV-1 had a wide range of shedding magnitude and duration. Flunixin meglumine administration in BHV-1 challenged calves did not result in an increase in magnitude or duration of viral shedding.
dc.description.advisorMichael D. Apley
dc.description.degreeMaster of Science in Biomedical Sciences
dc.description.departmentDepartment of Clinical Sciences
dc.description.levelMasters
dc.description.sponsorshipKansas State University College of Veterinary Medicine Mentor Clinical, Applied, or. Translational Research Intramural Grant
dc.identifier.urihttps://hdl.handle.net/2097/44906
dc.subjectNon-steroidal anti-inflammatory
dc.subjectflunixin meglumine
dc.subjectviral shedding
dc.titleThe effects of flunixin meglumine on viral shedding in calves
dc.typeThesis

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