An investigation of the oncogenic potential and function of the dual specificity phosphatase 12

dc.contributor.authorCain, Erica L.
dc.date.accessioned2013-10-18T15:27:21Z
dc.date.available2013-10-18T15:27:21Z
dc.date.graduationmonthMayen_US
dc.date.issued2013-10-18
dc.date.published2012en_US
dc.description.abstractLarge-scale genomic approaches have demonstrated many atypical dual specificity phosphatases (DUSPs) are differentially expressed or mutated in cancer. DUSPs are proteins predicted to have the ability to dephosphorylate Ser/Thr and Tyr residues, and the atypical DUSP subgroup contains at least 16 members with diverse substrates that include proteins, nucleic acids, and sugars, and some of the atypical DUSPs function in the cell not as phosphatases but as scaffolds in signal transduction pathways. Of the atypical DUSPs, DUSP12 is one of the most evolutionarily conserved with homologs found in organisms ranging from yeast to humans. DUSP12 is of particular interest as it has been identified to be one of only two candidate genes for the target of a genetic amplification found in liposarcomas. Furthermore, DUSP12 may be an oncogene in that over-expression of dusp12 in cell culture promotes apoptosis resistance, cell motility, and the up-regulation of two established oncogenes, the hepatocyte growth factor receptor (c-met) and integrin alpha 1 (itga1). Additionally, DUSP12 may protect from apoptosis by functioning as a regulator of stress-induced translation repression and stress granule formation that may be due to its interaction with the DEAD Box RNA Helicase, DDX3.en_US
dc.description.advisorAlexander E. Beeseren_US
dc.description.degreeDoctor of Philosophyen_US
dc.description.departmentDepartment of Biologyen_US
dc.description.levelDoctoralen_US
dc.identifier.urihttp://hdl.handle.net/2097/16694
dc.language.isoen_USen_US
dc.publisherKansas State Universityen
dc.subjectDUSP12en_US
dc.subjectYVH1en_US
dc.subjectAtypical DUSPen_US
dc.subjectCanceren_US
dc.subjectOncogeneen_US
dc.subjectDual specificity phosphataseen_US
dc.subject.umiCellular Biology (0379)en_US
dc.titleAn investigation of the oncogenic potential and function of the dual specificity phosphatase 12en_US
dc.typeDissertationen_US

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