Effect of Sucralfate on the Relative Bioavailability of Enrofloxacin and Ciprofloxacin in Healthy Fed Dogs
| dc.citation.doi | 10.1111/jvim.13796 | en_US |
| dc.citation.jtitle | Journal of Veterinary Internal Medicine | en_US |
| dc.contributor.author | KuKanich, Katherine | en_US |
| dc.contributor.author | KuKanich, Butch | en_US |
| dc.contributor.author | Guess, S. | en_US |
| dc.contributor.author | Heinrich, E. | en_US |
| dc.contributor.authoreid | kstenske | en_US |
| dc.contributor.authoreid | kukanich | en_US |
| dc.date.accessioned | 2016-01-19T20:30:22Z | |
| dc.date.available | 2016-01-19T20:30:22Z | |
| dc.date.issued | 2015-12-09 | |
| dc.date.published | 2015 | en_US |
| dc.description | Background: Sucralfate impairs absorption of ciprofloxacin and other fluoroquinolones in humans, but no sucralfate-fluoroquinolone interaction has been reported in dogs. Veterinary formularies recommend avoiding concurrent administration of these medications, which might impact compliance, therapeutic success, and resistance selection from fluoroquinolones. Objectives: To determine whether a drug interaction exists when sucralfate is administered to fed dogs concurrently with ciprofloxacin or enrofloxacin, and whether a 2 hour delay between fluoroquinolone and sucralfate affects fluoroquinolone absorption. Animals: Five healthy Greyhounds housed in a research colony. Methods: This was a randomized crossover study. Treatments included oral ciprofloxacin (C) or oral enrofloxacin (E) alone, each fluoroquinolone concurrently with an oral suspension of sucralfate (CS, ES), and sucralfate suspension 2 hours after each fluoroquinolone (C2S, E2S). Fluoroquinolone concentrations were evaluated using liquid chromatography with mass spectrometry. Results: Drug exposure of ciprofloxacin was highly variable (AUC 5.52-22.47 h ?g/mL) compared to enrofloxacin (AUC 3.86-7.50 h ?g/mL). The mean relative bioavailability for ciprofloxacin and concurrent sucralfate was 48% (range 8-143%) compared to ciprofloxacin alone. Relative bioavailability of ciprofloxacin improved to 87% (range 37-333%) when sucralfate was delayed by 2 hours. By contrast, relative bioavailability for enrofloxacin and concurrent sucralfate was 104% (94-115%). | en_US |
| dc.description | Citation: KuKanich, K., KuKanich, B., Guess, S. and Heinrich, E. (2015), Effect of Sucralfate on the Relative Bioavailability of Enrofloxacin and Ciprofloxacin in Healthy Fed Dogs. Journal of Veterinary Internal Medicine. doi: 10.1111/jvim.13796 | en_US |
| dc.identifier.uri | http://hdl.handle.net/2097/27634 | |
| dc.relation.uri | http://doi.org/10.1111/jvim.13796 | en_US |
| dc.rights | Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | en_US |
| dc.subject | Canine | en_US |
| dc.subject | Drug interaction; | en_US |
| dc.subject | Fluoroquinolone | en_US |
| dc.subject | Pharmacokinetics | en_US |
| dc.title | Effect of Sucralfate on the Relative Bioavailability of Enrofloxacin and Ciprofloxacin in Healthy Fed Dogs | en_US |
| dc.type | Text | en_US |
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