A blinded, randomized, placebo-controlled prospective study of the impact of the effect of photobiomodulation therapy in dogs with cranial cruciate ligament rupture after TPLO surgery.

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Abstract

Objective: Effect of photobiomodulation therapy (PBMT) in patients with CCLR after TPLO surgery by measuring C-reactive protein, percentage weight bearing, lameness using a short form of a composite measure pain scale, evaluated by the clinician and owners, and surgical site infection. Sample population: 54 client-owned dogs with CCLR undergoing unilateral TPLO surgery were enrolled in this study between April 5, 2021 – April 10, 2022. Methods: The study population was randomly assigned to either a treatment group receiving PMBT (24 dogs) or control group (30 dogs). PMBT was performed on the treatment group immediately after induction, and 6 hours, 24 hours, 48 hours and 8 weeks post-operatively. The control group received sham PMBT (device turned off) same time. Evaluation of CRP, CMPS-SF, evidence of SSI, and %WB were evaluated for all dogs 24 hours pre-operatively, and then 24 hours, 48 hours, and 8 weeks post-operatively. Owners completed CMPS-SF and subjective evaluations weekly for 8 weeks post-operatively.
Results: No statistically significant differences were found between treatment groups when evaluating CRP, %WB and CMPS-SF by clinician and weekly evaluation of the CMPS-SF by owners. Although no statistically significant differences were found on patients developing surgical site infections between treatment groups, SSI were only observed in patients in the control group (5/30, 16.6%). Most were minor/superficial infections (4/30 13.3%), and a single dog (1/30, 3.3%) had a major/deep surgical site infection.
Clinical relevance: Although with promising but not statistically significant differences between groups, surgical site infections may be reduced after PBMT application.

Description

Keywords

PBMT, TPLO, CCLR, CRP, LASER

Graduation Month

August

Degree

Master of Science in Biomedical Sciences

Department

Department of Clinical Sciences

Major Professor

Walter C. Renberg

Date

2023

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Thesis

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