Drosophila Condensin II subunit Chromosome-associated protein D3 regulates cell fate determination through non-cell-autonomous signaling

dc.citation.doi10.1242/dev.133686
dc.citation.epage2802
dc.citation.issn0950-1991
dc.citation.issue15
dc.citation.jtitleDevelopment
dc.citation.spage2791
dc.citation.volume143
dc.contributor.authorKlebanow, L. R.
dc.contributor.authorPeshel, E. C.
dc.contributor.authorSchuster, A. T.
dc.contributor.authorDe, K.
dc.contributor.authorSarvepalli, K.
dc.contributor.authorLemieux, M. E.
dc.contributor.authorLenoir, J. J.
dc.contributor.authorMoore, A. W.
dc.contributor.authorMcDonald, Jocelyn A.
dc.contributor.authorLongworth, M. S.
dc.contributor.authoreidjmcdona
dc.contributor.kstateMcDonald, Jocelyn A.
dc.date.accessioned2017-11-30T21:40:24Z
dc.date.available2017-11-30T21:40:24Z
dc.date.published2016
dc.descriptionCitation: Klebanow, L. R., Peshel, E. C., Schuster, A. T., De, K., Sarvepalli, K., Lemieux, M. E., . . . Longworth, M. S. (2016). Drosophila Condensin II subunit Chromosome-associated protein D3 regulates cell fate determination through non-cell-autonomous signaling. Development, 143(15), 2791-2802. doi:10.1242/dev.133686
dc.description.abstractThe pattern of the Drosophila melanogaster adult wing is heavily influenced by the expression of proteins that dictate cell fate decisions between intervein and vein during development. dSRF (Blistered) expression in specific regions of the larval wing disc promotes intervein cell fate, whereas EGFR activity promotes vein cell fate. Here, we report that the chromatin-organizing protein CAP-D3 acts to dampen dSRF levels at the anterior/posterior boundary in the larval wing disc, promoting differentiation of cells into the anterior crossvein. CAP-D3 represses KNOT expression in cells immediately adjacent to the anterior/posterior boundary, thus blocking KNOT-mediated repression of EGFR activity and preventing cell death. Maintenance of EGFR activity in these cells depresses dSRF levels in the neighboring anterior crossvein progenitor cells, allowing them to differentiate into vein cells. These findings uncover a novel transcriptional regulatory network influencing Drosophila wing vein development, and are the first to identify a Condensin II subunit as an important regulator of EGFR activity and cell fate determination in vivo.
dc.identifier.urihttp://hdl.handle.net/2097/38316
dc.relation.urihttps://doi.org/10.1242/dev.133686
dc.rightsAttribution 3.0 Unported (CC BY 3.0)
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/
dc.subjectDcap-D3
dc.subjectKnot
dc.subjectEgfr
dc.subjectSerum Response Factor
dc.subjectDsrf
dc.subjectVein Development
dc.titleDrosophila Condensin II subunit Chromosome-associated protein D3 regulates cell fate determination through non-cell-autonomous signaling
dc.typeArticle

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