A new class of cyclin dependent kinase in chlamydomonas is required for coupling cell size to cell division
dc.citation.doi | 10.7554/eLife.10767 | |
dc.citation.issn | 2050-084X | |
dc.citation.jtitle | eLife | |
dc.citation.volume | 5 | |
dc.contributor.author | Li, Y. | |
dc.contributor.author | Liu, D. | |
dc.contributor.author | López-Paz, C. | |
dc.contributor.author | Olson, Bradley J. | |
dc.contributor.author | Umen, J. G. | |
dc.contributor.authoreid | bjsco | |
dc.date.accessioned | 2016-09-20T14:53:46Z | |
dc.date.available | 2016-09-20T14:53:46Z | |
dc.date.published | 2016 | |
dc.description | Citation: Li, Y., Liu, D., López-Paz, C., Olson, B. J. S. C., & Umen, J. G. (2016). A new class of cyclin dependent kinase in chlamydomonas is required for coupling cell size to cell division. eLife, 5(MARCH2016). doi:10.7554/eLife.10767 | |
dc.description.abstract | Proliferating cells actively control their size by mechanisms that are poorly understood. The unicellular green alga Chlamydomonas reinhardtii divides by multiple fission, wherein a ‘counting’ mechanism couples mother cell-size to cell division number allowing production of uniform-sized daughters. We identified a sizer protein, CDKG1, that acts through the retinoblastoma (RB) tumor suppressor pathway as a D-cyclin-dependent RB kinase to regulate mitotic counting. Loss of CDKG1 leads to fewer mitotic divisions and large daughters, while mis-expression of CDKG1 causes supernumerous mitotic divisions and small daughters. The concentration of nuclear-localized CDKG1 in pre-mitotic cells is set by mother cell size, and its progressive dilution and degradation with each round of cell division may provide a link between mother cell-size and mitotic division number. Cell-size-dependent accumulation of limiting cell cycle regulators such as CDKG1 is a potentially general mechanism for size control. © Li et al. | |
dc.identifier.uri | http://hdl.handle.net/2097/33960 | |
dc.relation.uri | https://doi.org/10.7554/eLife.10767 | |
dc.rights | Attribution 4.0 International (CC BY 4.0) | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | A new class of cyclin dependent kinase in chlamydomonas is required for coupling cell size to cell division | |
dc.type | Article |
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