Experimental infection of calves by two genetically-distinct strains of rift valley fever virus

dc.citation.doi10.3390/v8050145
dc.citation.issn0375-8427
dc.citation.issue5
dc.citation.jtitleViruses
dc.citation.volume8
dc.contributor.authorWilson, William C.
dc.contributor.authorDavis, A. Sally
dc.contributor.authorGaudreault, Natasha N.
dc.contributor.authorFaburay, Bonto
dc.contributor.authorTrujillo, J. D.
dc.contributor.authorShivanna, V.
dc.contributor.authorSunwoo, S. Y.
dc.contributor.authorBalogh, A.
dc.contributor.authorEndalew, A.
dc.contributor.authorMa, Wenjun
dc.contributor.authorDrolet, B. S.
dc.contributor.authorRuder, M. G.
dc.contributor.authorMorozov, I.
dc.contributor.authorRicht, Juergen A.
dc.contributor.authoreidasally
dc.contributor.authoreidnng5757
dc.contributor.authoreidbfaburay
dc.contributor.authoreidwjma
dc.contributor.authoreidjricht
dc.date.accessioned2016-09-20T17:34:07Z
dc.date.available2016-09-20T17:34:07Z
dc.date.issued2016-05-23
dc.date.published2016
dc.descriptionCitation: Wilson, W. C., Davis, A. S., Gaudreault, N. N., Faburay, B., Trujillo, J. D., Shivanna, V., . . . Richt, J. A. (2016). Experimental infection of calves by two genetically-distinct strains of rift valley fever virus. Viruses, 8(5). doi:10.3390/v8050145
dc.descriptionAdditional Authors: McVey, D. S.
dc.description.abstractRecent outbreaks of Rift Valley fever in ruminant livestock, characterized by mass abortion and high mortality rates in neonates, have raised international interest in improving vaccine control strategies. Previously, we developed a reliable challenge model for sheep that improves the evaluation of existing and novel vaccines in sheep. This sheep model demonstrated differences in the pathogenesis of Rift Valley fever virus (RVFV) infection between two genetically-distinct wild-type strains of the virus, Saudi Arabia 2001 (SA01) and Kenya 2006 (Ken06). Here, we evaluated the pathogenicity of these two RVFV strains in mixed breed beef calves. There was a transient increase in rectal temperatures with both virus strains, but this clinical sign was less consistent than previously reported with sheep. Three of the five Ken06-infected animals had an early-onset viremia, one day post-infection (dpi), with viremia lasting at least three days. The same number of SA01-infected animals developed viremia at 2 dpi, but it only persisted through 3 dpi in one animal. The average virus titer for the SA01-infected calves was 1.6 logs less than for the Ken06-infected calves. Calves, inoculated with either strain, seroconverted by 5 dpi and showed time-dependent increases in their virus-neutralizing antibody titers. Consistent with the results obtained in the previous sheep study, elevated liver enzyme levels, more severe liver pathology and higher virus titers occurred with the Ken06 strain as compared to the SA01 strain. These results demonstrate the establishment of a virulent challenge model for vaccine evaluation in calves. © 2016 by the authors; licensee MDPI, Basel, Switzerland.
dc.identifier.urihttp://hdl.handle.net/2097/34069
dc.relation.urihttps://doi.org/10.3390/v8050145
dc.rightsAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCattle
dc.subjectChallenge Model
dc.subjectPathogenicity
dc.subjectRift Valley Fever
dc.subjectRift Valley Fever Virus
dc.titleExperimental infection of calves by two genetically-distinct strains of rift valley fever virus
dc.typeArticle

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