Timing, reward processing and choice behavior in four strains of rats with different levels of impulsivity.

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dc.contributor.author Garcia Aguirre, Ana I.
dc.date.accessioned 2011-07-22T14:03:35Z
dc.date.available 2011-07-22T14:03:35Z
dc.date.issued 2011-07-22
dc.identifier.uri http://hdl.handle.net/2097/10743
dc.description.abstract Several studies have examined timing and impulsive choice behavior in spontaneously hypertensive rats (SHR) as a possible pre-clinical model for Attention Deficit Hyperactivity Disorder (ADHD). However, the strain has not been specifically selected for the traits of ADHD and as a result their appropriateness as a model has been questioned. This study investigated whether SHR would exhibit timing deficits, poor reward processing and impulsive behavior in comparison to the Wistar Kyoto (WKY) control strain in a discrete-trial choice task. In addition, as a first approach to find another potential animal model of ADHD, we evaluated a strain that has shown high levels of impulsivity, the Lewis (LEW) rats and compared them with the Wistar (WIS) rats. In the first phase of the experiment, rats could chose a lever associated with a Smaller-sooner (SS) reward of 1 pellet delivered after 10 s and a Larger-later (LL) reward of 2 pellets delivered after 30 s. Subsequently, the rats were exposed to different phases, where the reward on the LL choice was increased to 3 and 4 pellets and where the delay to the SS choice was increased to 15 and 20 s. The SHR and WKY strains did not differ in their timing or choice behavior. In comparison to WIS, LEW showed timing deficits in both manipulations and deficits in choice behavior in the delay manipulation, indicating deficits in time processing. Individual differences among the rat within a strain accounted a significant proportion of the total variance and contributed more variance than the strain of the rat. These results indicate that the SHR and LEW strains are not sufficiently homogeneous with respect to impulsive choice behavior to be considered as viable models for impulse control disorders such as ADHD. en_US
dc.description.sponsorship Consejo Nacional de Ciencia y Tecnología en_US
dc.language.iso en en_US
dc.publisher Kansas State University en
dc.subject Timing en_US
dc.subject Reward Processing en_US
dc.subject Choice Behavior en_US
dc.subject Impulsivity en_US
dc.subject Wistar Kyoto (WKY) rats en_US
dc.subject Spontaneously Hypertensive Rats (SHR) en_US
dc.title Timing, reward processing and choice behavior in four strains of rats with different levels of impulsivity. en_US
dc.type Thesis en_US
dc.description.degree Master of Science en_US
dc.description.level Masters en_US
dc.description.department Department of Psychology en_US
dc.description.advisor Kimberly Kirkpatrick en_US
dc.subject.umi Psychology, Behavioral (0384) en_US
dc.date.published 2011 en_US
dc.date.graduationmonth August en_US

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