Process control in cell culture technology using dielectric spectroscopy

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dc.contributor.author Justice, C.
dc.contributor.author Brix, A.
dc.contributor.author Friemark, D.
dc.contributor.author Kraume, M.
dc.contributor.author Pfromm, Peter H.
dc.contributor.author Eichenmueller, B.
dc.contributor.author Czermak, Peter
dc.date.accessioned 2011-05-11T17:22:15Z
dc.date.available 2011-05-11T17:22:15Z
dc.date.issued 2011-05-11
dc.identifier.uri http://hdl.handle.net/2097/9100
dc.description.abstract In the biopharmaceutical industry, mammalian and insect cells as well as plant cell cultures are gaining worldwide importance to produce biopharmaceuticals and as products themselves, for example in stem cell therapy. These highly sophisticated cell-based production processes need to be monitored and controlled to guarantee product quality and to satisfy GMP requirements. With the process analytical technology (PAT) initiative, requirements regarding process monitoring and control have changed and real-time in-line monitoring tools are now recommended. Dielectric spectroscopy (DS) can serve as a tool to satisfy some PAT requirements. DS has been used in the medical field for quite some time and it may allow real-time process monitoring of biological cell culture parameters. DS has the potential to enable process optimization, automation, cost reduction, and a more consistent product quality. Dielectric spectroscopy is reviewed here as a tool to monitor biochemical processes. Commercially available dielectric sensing systems are discussed. The potential of this technology is demonstrated through examples of current and potential future applications in research and industry for mammalian and insect cell culture. en_US
dc.relation.uri http://www.elsevier.com/locate/biotechadv/ en_US
dc.subject Dielectric spectroscopy en_US
dc.subject Cell culture technology en_US
dc.subject PAT en_US
dc.subject Biomass monitoring en_US
dc.subject Process control en_US
dc.title Process control in cell culture technology using dielectric spectroscopy en_US
dc.type Text en_US
dc.date.published 2011 en_US
dc.citation.doi doi:10.1016/j.biotechadv.2011.03.002 en_US
dc.citation.epage 401 en_US
dc.citation.issue 4 en_US
dc.citation.jtitle Biotechnology Advances en_US
dc.citation.spage 391 en_US
dc.citation.volume 29 en_US
dc.contributor.authoreid pczermak en_US
dc.contributor.authoreid pfromm en_US


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