Dietary interventions for reduced disease activity in patients with rheumatoid arthritis: a critical review

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dc.contributor.author Mallon, Kacie Michelle
dc.date.accessioned 2020-08-14T15:51:56Z
dc.date.available 2020-08-14T15:51:56Z
dc.date.issued 2020-08-01
dc.identifier.uri https://hdl.handle.net/2097/40835
dc.description.abstract Rheumatoid arthritis (RA) is a chronic autoimmune condition in which an inflammatory response causes permanent damage to the cartilage and bone of affected joints, and is often associated with additional systemic complications. The pathogenesis of RA is not fully understood, and standard treatment requires trial and error of pharmacological interventions that may have serious side effects. Evidence suggests that dietary interventions, when added to standard pharmacotherapies, may effectively mitigate disease progression and symptoms of RA. The aim of the current review was to evaluate existing research on dietary interventions for treatment of RA symptoms to determine which diet therapies may be effective for improving symptoms and inflammatory markers of disease activity. Relevant studies were identified within PubMed, and inclusion and exclusion criteria were established a priori. Included studies incorporated an experimental design, a diet therapy component, and human participants with an existing diagnosis of RA. Studies not available in the English language or as full text, were excluded. The initial search yielded 110 records, and after evaluation of inclusion and exclusion criteria and topic relevance, results of nineteen studies were synthesized for interpretation. Included study interventions varied by duration, participants, objective, and prescribed diet. Assessments of disease activity were categorized as subjective, semi-objective, or objective markers of symptoms and inflammation. The prescribed diets included a period of fasting followed by a plant-based diet, vegan diets, Mediterranean diets, and three other dietary interventions that were hypothesized to have anti-inflammatory effects in patients with RA. A reduction in overall disease activity was observed in all nineteen of the included studies. However, statistical significance was more prevalent for semi-objective measurements of disease activity than more subjective and objective measures. Overall, the current review suggests that plant-based dietary interventions may be effective for reducing subjective measures of disease activity in patients with rheumatoid arthritis. Additional high-quality and longer-term interventions are needed to identify which dietary components and additional dietary interventions may be beneficial for reducing objective inflammatory markers of disease activity, when added to pharmacological therapy in patients with RA. en_US
dc.language.iso en en_US
dc.subject Rheumatoid arthritis en_US
dc.subject Diet therapies en_US
dc.title Dietary interventions for reduced disease activity in patients with rheumatoid arthritis: a critical review en_US
dc.type Report en_US
dc.description.degree Master of Science en_US
dc.description.level Masters en_US
dc.description.department Department of Food, Nutrition, Dietetics and Health en_US
dc.description.advisor Sara Rosenkranz en_US
dc.date.published 2020 en_US
dc.date.graduationmonth August en_US


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