Zearalenone Promotes Cell Proliferation or Causes Cell Death?

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dc.contributor.author Zheng, Wanglong
dc.contributor.author Wang, Bingjie
dc.contributor.author Li, Xi
dc.contributor.author Wang, Tao
dc.contributor.author Zou, Hui
dc.contributor.author Gu, Jianhong
dc.contributor.author Yuan, Yan
dc.contributor.author Liu, Xuezhong
dc.contributor.author Bai, Jianfa
dc.contributor.author Bian, Jianchun
dc.contributor.author Liu, Zongping
dc.date.accessioned 2018-12-14T17:10:20Z
dc.date.available 2018-12-14T17:10:20Z
dc.date.issued 2018-05-02
dc.identifier.uri http://hdl.handle.net/2097/39406
dc.description Citation: Zheng, W.; Wang, B.; Li, X.; Wang, T.; Zou, H.; Gu, J.; Yuan, Y.; Liu, X.; Bai, J.; Bian, J.; Liu, Z. Zearalenone Promotes Cell Proliferation or Causes Cell Death? Toxins 2018, 10, 184.
dc.description.abstract Zearalenone (ZEA), one of the mycotoxins, exerts different mechanisms of toxicity in different cell types at different doses. It can not only stimulate cell proliferation but also inhibit cell viability, induce cell apoptosis, and cause cell death. Thus, the objective of this review is to summarize the available mechanisms and current evidence of what is known about the cell proliferation or cell death induced by ZEA. An increasing number of studies have suggested that ZEA promoted cell proliferation attributing to its estrogen-like effects and carcinogenic properties. What’s more, many studies have indicated that ZEA caused cell death via affecting the distribution of the cell cycle, stimulating oxidative stress and inducing apoptosis. In addition, several studies have revealed that autophagy and some antioxidants can reverse the damage or cell death induced by ZEA. This review thoroughly summarized the metabolic process of ZEA and the molecular mechanisms of ZEA stimulating cell proliferation and cell death. It concluded that a low dose of ZEA can exert estrogen-like effects and carcinogenic properties, which can stimulate the proliferation of cells. While, in addition, a high dose of ZEA can cause cell death through inducing cell cycle arrest, oxidative stress, DNA damage, mitochondrial damage, and apoptosis.
dc.language.iso en_US
dc.relation.uri https://doi.org/10.3390/toxins10050184
dc.rights Attribution 4.0 International (CC BY 4.0)
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject Apoptosis
dc.subject Cell Death
dc.subject Cell Proliferation
dc.subject Estrogen-Like Effects
dc.subject Zearalenone
dc.title Zearalenone Promotes Cell Proliferation or Causes Cell Death?
dc.type Text
dc.date.published 2018
dc.citation.doi 10.3390/toxins10050184
dc.citation.issn 2072-6651
dc.citation.issue 5
dc.citation.jtitle Toxins
dc.citation.spage 184
dc.citation.volume 10
dc.citation Zheng, W.; Wang, B.; Li, X.; Wang, T.; Zou, H.; Gu, J.; Yuan, Y.; Liu, X.; Bai, J.; Bian, J.; Liu, Z. Zearalenone Promotes Cell Proliferation or Causes Cell Death? Toxins 2018, 10, 184.
dc.description.version Article:Version of Record (VOR)


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