Evaluation of the Zoonotic Potential of Transmissible Mink Encephalopathy

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dc.contributor.author Comoy, Emmanuel E.
dc.contributor.author Mikol, Jacqueline
dc.contributor.author Ruchoux, Marie-Madeleine
dc.contributor.author Durand, Valérie
dc.contributor.author Luccantoni-Freire, Sophie
dc.contributor.author Dehen, Capucine
dc.contributor.author Correia, Evelyne
dc.contributor.author Casalone, Cristina
dc.contributor.author Richt, Juergen A.
dc.contributor.author Greenlee, Justin J.
dc.contributor.author Torres, Juan Maria
dc.contributor.author Brown, Paul
dc.contributor.author Deslys, Jean-Philippe
dc.date.accessioned 2018-12-14T17:10:19Z
dc.date.available 2018-12-14T17:10:19Z
dc.date.issued 2013-07-30
dc.identifier.uri http://hdl.handle.net/2097/39400
dc.description Citation: Comoy, E.E.; Mikol, J.; Ruchoux, M.-M.; Durand, V.; Luccantoni-Freire, S.; Dehen, C.; Correia, E.; Casalone, C.; Richt, J.A.; Greenlee, J.J.; Torres, J.M.; Brown, P.; Deslys, J.-P. Evaluation of the Zoonotic Potential of Transmissible Mink Encephalopathy. Pathogens 2013, 2, 520-532.
dc.description.abstract Successful transmission of Transmissible Mink Encephalopathy (TME) to cattle supports the bovine hypothesis for the still controversial origin of TME outbreaks. Human and primate susceptibility to classical Bovine Spongiform Encephalopathy (c-BSE) and the transmissibility of L-type BSE to macaques indicate a low cattle-to-primate species barrier. We therefore evaluated the zoonotic potential of cattle-adapted TME. In less than two years, this strain induced in cynomolgus macaques a neurological disease similar to L-BSE but distinct from c-BSE. TME derived from another donor species (raccoon) induced a similar disease with even shorter incubation periods. L-BSE and cattle-adapted TME were also transmissible to transgenic mice expressing human prion protein (PrP). Secondary transmissions to transgenic mice expressing bovine PrP maintained the features of the three tested bovine strains (cattle TME, c-BSE and L-BSE) regardless of intermediate host. Thus, TME is the third animal prion strain transmissible to both macaques and humanized transgenic mice, suggesting zoonotic potentials that should be considered in the risk analysis of animal prion diseases for human health. Moreover, the similarities between TME and L-BSE are highly suggestive of a link between these strains, and therefore the possible presence of L-BSE for many decades prior to its identification in USA and Europe.
dc.language.iso en_US
dc.relation.uri https://doi.org/10.3390/pathogens2030520
dc.rights Attribution 3.0 Unported (CC BY 3.0)
dc.rights.uri http://creativecommons.org/licenses/by/3.0/
dc.subject Cattle
dc.subject Primate
dc.subject Prion
dc.subject Raccoon
dc.subject Tme
dc.subject Transgenic Mice
dc.title Evaluation of the Zoonotic Potential of Transmissible Mink Encephalopathy
dc.type Text
dc.date.published 2013
dc.citation.doi 10.3390/pathogens2030520
dc.citation.epage 532
dc.citation.issn 2076-0817
dc.citation.issue 3
dc.citation.jtitle Pathogens
dc.citation.spage 520
dc.citation.volume 2
dc.citation Comoy, E.E.; Mikol, J.; Ruchoux, M.-M.; Durand, V.; Luccantoni-Freire, S.; Dehen, C.; Correia, E.; Casalone, C.; Richt, J.A.; Greenlee, J.J.; Torres, J.M.; Brown, P.; Deslys, J.-P. Evaluation of the Zoonotic Potential of Transmissible Mink Encephalopathy. Pathogens 2013, 2, 520-532.
dc.description.version Article:Version of Record (VOR)


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