Influence of Intestinal Microbiota Transplantation and NleH Expression on Citrobacter rodentium Colonization of Mice

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dc.contributor.author Wang, Gaochan
dc.contributor.author Feuerbacher, Leigh Ann
dc.contributor.author Hardwidge, Philip R.
dc.date.accessioned 2018-12-14T17:10:19Z
dc.date.available 2018-12-14T17:10:19Z
dc.date.issued 2018-03-30
dc.identifier.uri http://hdl.handle.net/2097/39396
dc.description Citation: Wang, G.; Feuerbacher, L.A.; Hardwidge, P.R. Influence of Intestinal Microbiota Transplantation and NleH Expression on Citrobacter rodentium Colonization of Mice. Pathogens 2018, 7, 35.
dc.description.abstract The intestinal microbiota plays an important role in regulating host resistance to enteric pathogens. The relative abundance of the microbiota is dependent upon both genetic and environmental factors. The attaching and effacing pathogens enteropathogenic Escherichia coli, enterohemorrhagic E. coli, and Citrobacter rodentium cause diarrheal disease and translocate type III secretion system effector proteins into host cells to inhibit pro-inflammatory host responses. Here we determined the influence of both the intestinal microbiota and the expression of the C. rodentium NleH effector on C. rodentium colonization in different mouse models. We performed fecal transplantation experiments between C57BL/6J and C57BL/10ScNJ mice and found that such microbiota transfers altered both the host resistance to C. rodentium infection as well as the benefit or detriment of expressing NleH to C. rodentium intestinal colonization.
dc.language.iso en_US
dc.relation.uri https://doi.org/10.3390/pathogens7020035
dc.rights Attribution 4.0 International (CC BY 4.0)
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject Citrobacter
dc.subject Colonization
dc.subject Microbiota
dc.title Influence of Intestinal Microbiota Transplantation and NleH Expression on Citrobacter rodentium Colonization of Mice
dc.type Text
dc.date.published 2018
dc.citation.doi 10.3390/pathogens7020035
dc.citation.issn 2076-0817
dc.citation.issue 2
dc.citation.jtitle Pathogens
dc.citation.spage 35
dc.citation.volume 7
dc.citation Wang, G.; Feuerbacher, L.A.; Hardwidge, P.R. Influence of Intestinal Microbiota Transplantation and NleH Expression on Citrobacter rodentium Colonization of Mice. Pathogens 2018, 7, 35.
dc.description.version Article:Version of Record (VOR)


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