A biometrical inheritance model for heritability under the presence of environmental exposures: application to Michigan fisheater data

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dc.contributor.author Zhu, Jiali
dc.date.accessioned 2018-11-16T21:52:30Z
dc.date.available 2018-11-16T21:52:30Z
dc.date.issued 2018-12-01
dc.identifier.uri http://hdl.handle.net/2097/39335
dc.description.abstract Polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) are endocrine disrupting chemicals which can imbalance the hormonal system in the human body and lead to deleterious diseases such as diabetes, irregular menstrual cycles, endometriosis, and breast cancer. These chemicals as environmental exposures still exist in the environment and food chains and can be accumulated in human fatty tissues for many years. These chemicals can also be passed from mothers to their children through placental transfer or breastfeeding; therefore, their offspring may be at increased risk of adverse health outcomes from these inherited chemicals. However, it is still unclear how the parental association with offspring health outcomes and the inter-generational phenotypic inheritance could be affected by these chemical compounds. In this study, we mainly focus on how PCBs and DDE can affect the inheritance of Body Mass Index (BMI) across generations, as BMI is the primary health outcome (or phenotype) linked to diabetes. We propose a biometrical inheritance model to investigate the effects of PCBs and DDE on the heritability of BMI over two generations. Technically, a linear mixed effects model is developed based on the decomposition of phenotypic variance and assuming the variance of the environmental effect depends on parental exposures. The proposed model is evaluated extensively by simulations and then is applied to Michigan Fisheater Cohort data for answering the research question of interest. en_US
dc.language.iso en_US en_US
dc.subject heritability en_US
dc.subject PCBs en_US
dc.subject DDE en_US
dc.subject BMI en_US
dc.subject Biometrical inheritance model en_US
dc.subject environmental exposures en_US
dc.title A biometrical inheritance model for heritability under the presence of environmental exposures: application to Michigan fisheater data en_US
dc.type Report en_US
dc.description.degree Master of Science en_US
dc.description.level Masters en_US
dc.description.department Department of Statistics en_US
dc.description.advisor Wei-Wen Hsu en_US
dc.date.published 2018 en_US
dc.date.graduationmonth December en_US

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