Dual-nozzle spray deposition process for improving the stability of proteins in polymer microneedles

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dc.contributor.author Kim, Min Jung
dc.contributor.author Parka, Seok Chan
dc.contributor.author Choi, Seong-O
dc.date.accessioned 2017-12-13T17:52:12Z
dc.date.available 2017-12-13T17:52:12Z
dc.identifier.uri http://hdl.handle.net/2097/38544
dc.description Citation: Kim, M. J., Park, S. C., & Choi, S.-O. (2017). Dual-nozzle spray deposition process for improving the stability of proteins in polymer microneedles. RSC Advances, 7(87), 55350–55359. https://doi.org/10.1039/C7RA10928H
dc.description.abstract Polymer microneedles are an attractive way of transdermal delivery of various pharmaceutical compounds. Fabrication of drug-encapsulating polymer microneedles, however, often involves processing conditions unfavorable for maintaining the stability of drugs, including highly concentrated formulations, high temperature and long drying time. The stability of labile substances in biodegradable polymer matrices could also be significantly reduced by the use of organic solvents and emulsification. In this paper, we reported a new fabrication technique called the dual-nozzle spray deposition process, which utilizes a separate deposition of drug and polymer solutions, as a potential way to address the stability issue associated with current microneedle fabrication processes. A model protein, bovine serum albumin (BSA), was successfully incorporated into both water-soluble poly(vinyl alcohol) (PVA) and biodegradable poly(lactic-co-glycolic acid) (PLGA) microneedles by the dual-nozzle spray deposition process. The conformational change of BSA examined by circular dichroism and fluorescence spectroscopy suggests that the developed process helps maintain the structural stability of BSA during encapsulation in both PVA and PLGA matrices. We anticipate that the dual-nozzle spray deposition process would improve the stability of drugs by reducing adverse interaction with solvents and eliminating the emulsification process. Also, the developed process could be an attractive approach to fabricating polymer-based drug delivery devices.
dc.relation.uri https://doi.org/10.1039/C7RA10928H
dc.rights Attribution 3.0 Unported (CC BY 3.0)
dc.rights.uri https://creativecommons.org/licenses/by/3.0/
dc.title Dual-nozzle spray deposition process for improving the stability of proteins in polymer microneedles
dc.type Article
dc.date.published 2017
dc.citation.doi 10.1039/C7RA10928H
dc.citation.epage 55359
dc.citation.issn 2046-2069
dc.citation.issue 87
dc.citation.jtitle RSC Advances
dc.citation.spage 55350
dc.citation.volume 7
dc.contributor.authoreid mj1217
dc.contributor.authoreid schpark
dc.contributor.authoreid sochoi
dc.contributor.kstate Kim, Min Jung
dc.contributor.kstate Parka, Seok Chan
dc.contributor.kstate Choi, Seong-O


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Attribution 3.0 Unported (CC BY 3.0) Except where otherwise noted, the use of this item is bound by the following: Attribution 3.0 Unported (CC BY 3.0)

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