Development of methods for studying embryo-uterine interactions

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Show simple item record Zhang, Z. Davis, Duane L. 2010-04-09T15:31:32Z 2010-04-09T15:31:32Z 2010-04-09T15:31:32Z
dc.description.abstract The endometrium (lining of the uterus) functions to support and nurture developing embryos. However, 20 to 30% of pig embryos are lost in early pregnancy. Therefore, we developed methods to study the endometrium. Our initial work addresses the production of prostaglandins by the endometrium. Prostaglandins are known to play important roles in the establishment of pregnancy. In the pig, this process occurs near the end of the second week of pregnancy. Therefore, we determined the prostaglandin production by glandular and stromal cells of pig endometrium collected on d 13 of pregnancy. Glandular cells produced more prostaglandin F2α (PGF2α) than prostaglandin E (PGE). In contrast, stromal cells secreted more PGE than PGF2α. Progesterone inhibited PGE and PGF2α production by both glandular and stromal cells. Four-hydroxyestradiol, an estrogen produced by pig blastocysts and endometrium, inhibited PG production of both prostaglandins by glandular cells but stimulated prostaglandin production by stromal cells. Our data indicate that glandular and stromal cells of the pig endometrium possess different characteristics of prostaglandin production, and these differences may be important in conceptus signaling for the establishment and maintenance of pregnancy. en_US
dc.publisher Kansas State University. Agricultural Experiment Station and Cooperative Extension Service en_US
dc.relation.isPartOf Swine day, 1989 en_US
dc.relation.isPartOf Kansas Agricultural Experiment Station contribution; no. 90-163-S en_US
dc.relation.isPartOf Report of progress (Kansas State University. Agricultural Experiment Station and Cooperative Extension Service); 581 en_US
dc.subject Swine en_US
dc.subject Uterus en_US
dc.subject Embryo en_US
dc.subject Pregnancy en_US
dc.subject Prostaglandin en_US
dc.subject Estrogen en_US
dc.title Development of methods for studying embryo-uterine interactions en_US
dc.type Conference paper en_US 1989 en_US
dc.citation.epage 41 en_US
dc.citation.spage 39 en_US
dc.description.conference Swine Day, Manhattan, KS, November 16, 1989 en_US
dc.contributor.authoreid davis en_US

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