A Recombinant Rift Valley Fever Virus Glycoprotein Subunit Vaccine Confers Full Protection against Rift Valley Fever Challenge in Sheep

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dc.contributor.author Faburay, Bonto
dc.contributor.author Wilson, William C.
dc.contributor.author Gaudreault, Natasha N.
dc.contributor.author Davis, A. S.
dc.contributor.author Shivanna, Vinay
dc.contributor.author Bawa, Bhupinder
dc.contributor.author Sunwoo, Sun Young
dc.contributor.author Ma, Wenjun
dc.contributor.author Drolet, B. S.
dc.contributor.author Morozov, I.
dc.contributor.author McVey, D. S.
dc.contributor.author Richt, Juergen A.
dc.date.accessioned 2017-02-15T14:42:52Z
dc.date.available 2017-02-15T14:42:52Z
dc.date.issued 2016-06-14
dc.identifier.uri http://hdl.handle.net/2097/35171
dc.description Citation: Faburay, B., Wilson, W. C., Gaudreault, N. N., Davis, A. S., Shivanna, V., Bawa, B., . . . Richt, J. A. (2016). A Recombinant Rift Valley Fever Virus Glycoprotein Subunit Vaccine Confers Full Protection against Rift Valley Fever Challenge in Sheep. Scientific Reports, 6, 12. doi:10.1038/srep27719
dc.description.abstract Rift Valley fever virus (RVFV) is a mosquito-borne zoonotic pathogen causing disease outbreaks in Africa and the Arabian Peninsula. The virus has great potential for transboundary spread due to the presence of competent vectors in non-endemic areas. There is currently no fully licensed vaccine suitable for use in livestock or humans outside endemic areas. Here we report the evaluation of the efficacy of a recombinant subunit vaccine based on the RVFV Gn and Gc glycoproteins. In a previous study, the vaccine elicited strong virus neutralizing antibody responses in sheep and was DIVA (differentiating naturally infected from vaccinated animals) compatible. In the current efficacy study, a group of sheep (n=5) was vaccinated subcutaneously with the glycoprotein-based subunit vaccine candidate and then subjected to heterologous challenge with the virulent Kenya-128B-15 RVFV strain. The vaccine elicited high virus neutralizing antibody titers and conferred complete protection in all vaccinated sheep, as evidenced by prevention of viremia, fever and absence of RVFV-associated histopathological lesions. We conclude that the subunit vaccine platform represents a promising strategy for the prevention and control of RVFV infections in susceptible hosts.
dc.relation.uri https://doi.org/10.1038/srep27719
dc.rights Attribution 4.0 International (CC BY 4.0)
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject Monoclonal-Antibodies
dc.subject Immune-Responses
dc.subject Efficacy
dc.subject Safety
dc.subject Expression
dc.subject Strain
dc.title A Recombinant Rift Valley Fever Virus Glycoprotein Subunit Vaccine Confers Full Protection against Rift Valley Fever Challenge in Sheep
dc.type Article
dc.date.published 2016
dc.citation.doi 10.1038/srep27719
dc.citation.issn 2045-2322
dc.citation.jtitle Scientific Reports
dc.citation.spage 12
dc.citation.volume 6
dc.contributor.authoreid bfaburay
dc.contributor.authoreid nng5757
dc.contributor.authoreid asally
dc.contributor.authoreid wjma
dc.contributor.authoreid jricht
dc.contributor.kstate Faburay, Bonto
dc.contributor.kstate Gaudreault, Natasha N.
dc.contributor.kstate Davis, A. Sally
dc.contributor.kstate Ma, Wenjun
dc.contributor.kstate Richt, Juergen A.
dc.contributor.kstate Shivanna, Vinay
dc.contributor.kstate Bawa, Bhupinder
dc.contributor.kstate Sunwoo, Sun Young


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