Evolution of the Insertion-Deletion Mutation Rate Across the Tree of Life

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dc.contributor.author Sung, W.
dc.contributor.author Ackerman, M. S.
dc.contributor.author Dillon, M. M.
dc.contributor.author Platt, Thomas G.
dc.contributor.author Fuqua, C.
dc.contributor.author Cooper, V. S.
dc.contributor.author Lynch, M.
dc.date.accessioned 2017-02-14T23:08:41Z
dc.date.available 2017-02-14T23:08:41Z
dc.identifier.uri http://hdl.handle.net/2097/35142
dc.description Citation: Sung, W., Ackerman, M. S., Dillon, M. M., Platt, T. G., Fuqua, C., Cooper, V. S., & Lynch, M. (2016). Evolution of the Insertion-Deletion Mutation Rate Across the Tree of Life. G3-Genes Genomes Genetics, 6(8), 2583-2591. doi:10.1534/g3.116.030890/-/DC1
dc.description.abstract Mutations are the ultimate source of variation used for evolutionary adaptation, while also being predominantly deleterious and a source of genetic disorders. Understanding the rate of insertion-deletion mutations (indels) is essential to understanding evolutionary processes, especially in coding regions, where such mutations can disrupt production of essential proteins. Using direct estimates of indel rates from 14 phylogenetically diverse eukaryotic and bacterial species, along with measures of standing variation in such species, we obtain results that imply an inverse relationship of mutation rate and effective population size. These results, which corroborate earlier observations on the base-substitution mutation rate, appear most compatible with the hypothesis that natural selection reduces mutation rates per effective genome to the point at which the power of random genetic drift (approximated by the inverse of effective population size) becomes overwhelming. Given the substantial differences in DNA metabolism pathways that give rise to these two types of mutations, this consistency of results raises the possibility that refinement of other molecular and cellular traits may be inversely related to species-specific levels of random genetic drift.
dc.relation.uri https://doi.org/10.1534/g3.116.030890
dc.rights Attribution 4.0 International (CC BY 4.0)
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject Insertion-Deletion Mutation Rate
dc.subject Mutation-Rate Evolution
dc.subject Drift
dc.subject Barrier
dc.subject Mutation Accumulation
dc.subject De-Novo Mutations
dc.title Evolution of the Insertion-Deletion Mutation Rate Across the Tree of Life
dc.type Article
dc.date.published 2016
dc.citation.doi 10.1534/g3.116.030890
dc.citation.epage 2591
dc.citation.issn 2160-1836
dc.citation.issue 8
dc.citation.jtitle G3-Genes Genomes Genetics
dc.citation.spage 2583
dc.citation.volume 6
dc.contributor.authoreid tgplatt
dc.contributor.kstate Platt, Thomas G.


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