Impact of carprofen administration on stress and nociception responses of calves to cautery dehorning

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dc.contributor.author Stock, M. L.
dc.contributor.author Barth, L. A.
dc.contributor.author Van Engen, N. K.
dc.contributor.author Millman, S. T.
dc.contributor.author Gehring, Ronette
dc.contributor.author Wang, C.
dc.contributor.author Voris, E. A.
dc.contributor.author Wulf, L. W.
dc.contributor.author Labeur, L.
dc.contributor.author Hsu, W. H.
dc.contributor.author Coetzee, J. F.
dc.date.accessioned 2016-09-20T17:37:30Z
dc.date.available 2016-09-20T17:37:30Z
dc.identifier.uri http://hdl.handle.net/2097/34088
dc.description Citation: Stock, M. L., Barth, L. A., Van Engen, N. K., Millman, S. T., Gehring, R., Wang, C., . . . Coetzee, J. F. (2016). Impact of carprofen administration on stress and nociception responses of calves to cautery dehorning. Journal of Animal Science, 94(2), 542-555. doi:10.2527/jas2015-9510
dc.description.abstract The objective of this study was to investigate the effects of carprofen administered immediately before cautery dehorning on nociception and stress. Forty Holstein calves aged approximately 6 to 8 wk old were either placebo treated and sham dehorned (n = 10) or cautery dehorned following administration of carprofen (1.4 mg/kg) subcutaneously (n = 10) or orally (n = 10) or a subcutaneous and oral placebo (n = 10) in a randomized, controlled trial. All animals were given a cornual nerve block using lidocaine before dehorning. Response variables including mechanical nociception threshold, ocular temperature, heart rate, and respiratory rate were measured before and following cautery dehorning for 96 h. Blood samples were also collected over 96 h following dehorning and analyzed for plasma cortisol and substance P concentrations by RIA. Plasma carprofen concentration and ex vivo PGE2 concentrations were also determined for this time period. Average daily gain was calculated for 7 d after dehorning. Data were analyzed using a linear mixed effects model with repeated measures, controlling for baseline values by their inclusion as a covariate in addition to planned contrasts. Dehorning was associated with decreased nociception thresholds throughout the study and a stress response immediately after dehorning, following the loss of local anesthesia, and 48 h after dehorning compared with sham-dehorned calves. Carprofen was well absorbed after administration and reached concentrations that inhibited ex vivo PGE2 concentrations for 72 h (subcutaneous) and 96 h (oral) compared with placebo-treated calves (P < 0.05). Carprofen-treated calves tended to be less sensitive (P = 0.097) to nociceptive threshold tests. Overall, at the dosing regimen studied, the effect of carprofen on sensitivity and stress following cautery dehorning was minimal. Consideration of route of administration and dose determination studies may be warranted.
dc.relation.uri https://doi.org/10.2527/jas2015-9510
dc.rights Copyright © 2016. American Society of Animal Science.
dc.rights.uri http://www.sherpa.ac.uk/romeo/issn/0021-8812/
dc.subject Animal Welfare
dc.subject Dehorning
dc.subject Nociception
dc.subject Nonsteroidal Anti-Inflammatory
dc.subject Drugs
dc.subject Stress
dc.title Impact of carprofen administration on stress and nociception responses of calves to cautery dehorning
dc.type Article
dc.date.published 2016
dc.citation.doi 10.2527/jas2015-9510
dc.citation.epage 555
dc.citation.issn 0021-8812
dc.citation.issue 2
dc.citation.jtitle Journal of Animal Science
dc.citation.spage 542
dc.citation.volume 94
dc.description.embargo 2017-01
dc.contributor.authoreid rgehring


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