PB2-588 V promotes the mammalian adaptation of H10N8, H7N9 and H9N2 avian influenza viruses

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dc.contributor.author Xiao, C. C.
dc.contributor.author Ma, Wenjun
dc.contributor.author Sun, N.
dc.contributor.author Huang, L. H.
dc.contributor.author Li, Y. L.
dc.contributor.author Zeng, Z. Y.
dc.contributor.author Wen, Y. J.
dc.contributor.author Zhang, Z. Y.
dc.contributor.author Li, H. A.
dc.contributor.author Li, Q.
dc.contributor.author Yu, Y. D.
dc.contributor.author Zheng, Y.
dc.contributor.author Liu, S. K.
dc.contributor.author Hu, P. S.
dc.date.accessioned 2016-09-20T17:34:06Z
dc.date.available 2016-09-20T17:34:06Z
dc.date.issued 2016-01-19
dc.identifier.uri http://hdl.handle.net/2097/34066
dc.description Citation: Xiao, C. C., Ma, W. J., Sun, N., Huang, L. H., Li, Y. L., Zeng, Z. Y., . . . Liao, M. (2016). PB2-588 V promotes the mammalian adaptation of H10N8, H7N9 and H9N2 avian influenza viruses. Scientific Reports, 6, 13. doi:10.1038/srep19474
dc.description Additional Authors: Zhang, X.;Ning, Z. Y.;Qi, W. B.;Liao, M.
dc.description.abstract Human infections with avian influenza H7N9 or H10N8 viruses have been reported in China, raising concerns that they might cause human epidemics and pandemics. However, how these viruses adapt to mammalian hosts is unclear. Here we show that besides the commonly recognized viral polymerase subunit PB2 residue 627 K, other residues including 87E, 292 V, 340 K, 588 V, 648 V, and 676 M in PB2 also play critical roles in mammalian adaptation of the H10N8 virus. The avian-origin H10N8, H7N9, and H9N2 viruses harboring PB2-588V exhibited higher polymerase activity, more efficient replication in mammalian and avian cells, and higher virulence in mice when compared to viruses with PB2-588 A. Analyses of available PB2 sequences showed that the proportion of avian H9N2 or human H7N9 influenza isolates bearing PB2-588 V has increased significantly since 2013. Taken together, our results suggest that the substitution PB2-A588V may be a new strategy for an avian influenza virus to adapt mammalian hosts.
dc.relation.uri https://doi.org/10.1038/srep19474
dc.rights Attribution 4.0 International (CC BY 4.0)
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject A H5N1 Virus
dc.subject Amino-Acid Changes
dc.subject Receptor-Binding
dc.subject Human Infection
dc.subject Molecular-Basis
dc.subject Cell Tropism
dc.title PB2-588 V promotes the mammalian adaptation of H10N8, H7N9 and H9N2 avian influenza viruses
dc.type Article
dc.date.published 2016
dc.citation.doi 10.1038/srep19474
dc.citation.issn 2045-2322
dc.citation.jtitle Scientific Reports
dc.citation.spage 13
dc.citation.volume 6
dc.contributor.authoreid wjma

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Attribution 4.0 International (CC BY 4.0) Except where otherwise noted, the use of this item is bound by the following: Attribution 4.0 International (CC BY 4.0)

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